Evidence for widespread infection of hepatitis E virus among wild rats in Japan

被引：70
作者：
Hirano, M
Ding, X
Li, TC
Takeda, N
Kawabata, H
Koizumi, N
Kadosaka, T
Goto, I
Masuzawa, T
Nakamura, M
Taira, K
Kuroki, T
Tanikawa, T
Watanabe, H
Abe, K
机构：
[1] Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628640, Japan
[2] Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan
[3] Natl Inst Infect Dis, Dept Bacteriol 1, Tokyo, Japan
[4] Aichi Med Univ, Sch Med, Dept Parasitol, Aichi, Japan
[5] Nagoya Quarantine Off, Aichi, Japan
[6] Univ Shizuoka, Sch Pharmaceut Sci, Dept Microbiol, Shizuoka, Japan
[7] Univ Shizuoka, Sch Pharmaceut Sci, COE Program Century 21, Shizuoka, Japan
[8] Okinawa Prefectural Inst Hlth & Environm, Okinawa, Japan
[9] Kanagawa Prefectural Publ Hlth Lab, Dept Bacteriol & Pathol, Kanagawa, Japan
[10] IKARI Co Ltd, Tech Res Lab, Chiba, Japan
来源：
HEPATOLOGY RESEARCH | 2003年 / 27卷 / 01期
关键词：
hepatitis E virus (HEV); prevalence of anti-HEV in rats; animal reservoir; zoonosis;
D O I：
10.1016/S1386-6346(03)00192-X
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Sporadic cases of hepatitis E have been reported in industrialized countries, including Japan. The source of hepatitis E virus (HEV) in these patients is unknown, although zoonotic transmission has been suggested. To investigate whether or not rodents might be a reservoir of HEV, we conducted an epidemiological survey for the antibody to a recombinant capsid protein of HEV using serum samples from wild rodents in Japan. One hundred and fourteen of 362 (31.5%) Norway rats (Rattus norvegicus) and 12 of 90 (13.3%) black rats (Rattus rattus) were positive for anti-HEV IgG. In contrast, all of the sera from 55 mice were negative for anti-HEV IgG. The rate of antibody positivity increased with weight among Norway rats. Seropositive rats were found in all five districts surveyed in this study, but the prevalence of anti-HEV IgG in wild rats differed among these prefectures. Despite the fact that Japan is a non-endemic country of hepatitis E, widespread infection of HEV was observed among wild rats in Japan. Our results suggested that HEV or a closely related virus is circulating among wild rats in Japan. (C) 2003 Elsevier Science B.V. All rights reserved.
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页码：1 / 5
页数：5
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