Electrophysiological evidence for selective impairment of optic flow perception in autism spectrum disorder

被引：13

作者：

Yamasaki, Takao ^{[1
]}

Fujita, Takako ^{[1
,2
]}

Ogata, Katsuya ^{[1
]}

Goto, Yoshinobu ^{[3
]}

Munetsuna, Shinji ^{[4
]}

Kamio, Yoko ^{[5
]}

Tobimatsu, Shozo ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Neurol Inst, Dept Clin Neurophysiol,Higashi Ku, Fukuoka 8128582, Japan

[2] Fukuoka Univ, Sch Med, Dept Pediat, Fukuoka 81401, Japan

[3] Int Univ Hlth & Welf, Fac Rehabil, Dept Occupat Therapy, Okawa, Japan

[4] Kyushu Inst Technol, Grad Sch Life Sci & Syst Engn, Dept Brain Sci & Engn, Kitakyushu, Fukuoka 804, Japan

[5] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Child & Adolescent Mental Hlth, Tokyo, Japan

来源：

RESEARCH IN AUTISM SPECTRUM DISORDERS | 2011年 / 5卷 / 01期

关键词：

Autism spectrum disorder; Coherent motion perception; Optic flow; Dorso-dorsal pathway; Ventro-dorsal pathway; Event-related potentials; VISUAL-EVOKED-POTENTIALS; MOTION COHERENCE; ASPERGER SYNDROME; QUOTIENT AQ; AREA MT; CHILDREN; FORM; IDENTIFICATION; INFORMATION; THRESHOLDS;

D O I：

10.1016/j.rasd.2010.06.002

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

People with autism spectrum disorder (ASD) often show inferior global motion performance with superior performance in detail form perception, suggesting dysfunction of the dorsal visual stream. To elucidate the neural basis of impaired global motion perception in ASD, we measured psychophysical threshold and visual event-related potentials (ERPs) with a 128-channel system in 12 ASD and 12 healthy control adults. Radial optic flow (OF) and horizontal motion (HO) were used as the visual stimuli. The former was related to the ventro-dorsal stream formed by the inferior parietal lobule, while the latter was conveyed from the dorso-dorsal stream formed by the superior parietal lobule. No significant group differences were observed in the motion thresholds for both OF and HO. N170 and P200 were elicited as major components of ERPs in both groups. However, the latencies of both components for OF but not HO were significantly prolonged in ASD compared with the control group. Our ERP results suggest that ASD has a selective impairment for OF processing even though the psychophysical thresholds are preserved. Therefore, we provide the first electrophysiological evidence for altered function of the higher-level dorsal visual stream in ASD, specifically the ventro-dorsal stream closely related to OF perception. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：400 / 407

页数：8

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