2-Pyridylphosphonates: a new type of modification for nucleotide analogues

被引：31

作者：

Johansson, T

Kers, A

Stawinski, J ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[2] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(01)00115-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Suitably protected dithymidine H-phosphonates afforded the corresponding dinucleoside 2-pyridylphosphonates upon treatment with N-methoxypyridinium tosylate in acetonitrile in the presence of 1,8-diazabicylo[5.4.0]undec-7-ene (DBU). The reaction was rapid (ca. 5 min), practically quantitative and proceeded stereospecifically, most likely with retention of configuration at the phosphorus centre. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2217 / 2220

页数：4

共 23 条

[1]

ACHREMOWICZ L, 1975, SYNTHESIS-STUTTGART, P653

[2]

Akiba K., 1986, Jp. Pat., Kokai Tokkyo Koho, Patent No. 61221102

[3] MICHAELIS-ARBUZOV-REACTION OF PERHALOGENATED PYRIDINES [J].