Human T-Cell leukemia virus type 1 Tax and cellular transformation

被引：30
作者：
Peloponese, Jean-Marie, Jr. [1 ]
Kinjo, Takao [1 ]
Jeang, Kuan-Teh [1 ]
机构：
[1] NIAID, Natl Inst Hlth, Mol Microbiol Lab, Mol Virol Sect, Bethesda, MD USA
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 02期
关键词：
human T-cell leukemia virus 1 (HTLV-1); adult T-cell leukemia (ATL); Tax; NF-kappa B; transformation;
D O I：
10.1532/IJH97.07087
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Infection of T-cells by human T-cell leukemia virus type 1 (HTLV-1) causes a lymphoproliferative malignancy known as adult T-cell leukemia (ATL). ATL is characterized by abnormal lymphocytes, called flower cells, which have cleaved and convoluted nuclei. Tax, encoded by the HTLV-1 pX region, is a critical nonstructural protein that plays a central role in leukemogenesis; however, the mechanisms of HTLV-1 oncogenesis have not been clarified fully. In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis.
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收藏
页码：101 / 106
页数：6
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