Overview of serum and tissue markers in colorectal cancer: a primer for radiologists

被引：6

作者：

Bonde, Apurva ^{[1
]}

Smith, Daniel A. ^{[2
]}

Kikano, Elias ^{[2
]}

Yoest, Jennifer M. ^{[3
]}

Tirumani, Sree H. ^{[2
]}

Ramaiya, Nikhil H. ^{[2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[2] Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Dept Radiol, 11100 Euclid Ave, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Dept Pathol, 11100 Euclid Ave, Cleveland, OH 44106 USA

来源：

ABDOMINAL RADIOLOGY | 2021年 / 46卷 / 12期

关键词：

Colorectal cancer; Tissue and serum tumor markers; Liquid biopsy; Imaging; CIRCULATING TUMOR DNA; CARCINOEMBRYONIC ANTIGEN; THERAPY; EGFR; CHEMOTHERAPY; ASSOCIATION; RECURRENCE; BIOMARKERS; GUIDELINE; PATTERNS;

D O I：

10.1007/s00261-021-03243-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Serum and tissue tumor markers provide crucial information in the diagnosis, treatment, and follow-up of colorectal cancers. Tissue tumor markers are increasingly used for determination of targeted chemotherapy planning based on genotyping of tumor cells. Recently, plasma-based technique of liquid biopsy is being evaluated for providing tumor biomarkers in the management of colorectal cancer. Tumor markers are commonly used in conjunction with imaging during initial staging, treatment determination, response assessment, and determination of recurrence or metastatic disease. Knowledge of tumor markers and their association with radiological findings is thus crucial for radiologists. Additionally, various novel imaging techniques are being evaluated as potential noninvasive imaging biomarkers to predict tumor genotypes, features, and tumor response. We review and discuss the potential role of these newer imaging techniques. [GRAPHICS] .

引用

页码：5521 / 5535

页数：15

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