Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma: Same Disease Spectrum but Two Distinct Diagnoses

被引:9
作者
Kline, Kathryn A. F. [1 ]
Kallen, Michael E. [2 ]
Duong, Vu H. [1 ,3 ]
Law, Jennie Y. [1 ,3 ]
机构
[1] Univ Maryland, Greenebaum Comprehens Canc Ctr, 22 S Greene St,S9D10, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Dept Med, Div Hematol Oncol, Baltimore, MD 21201 USA
关键词
Acute lymphocytic leukemia; Lymphoblastic lymphoma; BCR-ABL; Tyrosine kinase inhibitors; CAR-T; BiTE; NON-HODGKIN-LYMPHOMA; BONE-MARROW INVOLVEMENT; YOUNG-ADULTS; HYPER-CVAD; PHASE-II; HYPERFRACTIONATED CYCLOPHOSPHAMIDE; GENOMIC LANDSCAPE; B-PRECURSOR; CHILDHOOD; CHILDREN;
D O I
10.1007/s11899-021-00648-y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose of Review Rare malignancies developing from lymphocyte precursor cells, lymphoblastic leukemia (LBL), and acute lymphoblastic lymphoma (ALL) have historically been viewed as different manifestations of the same disease process. This review examines data on their epidemiology, genetics, clinical presentation, and response to treatment while highlighting areas of similarity and divergence between these two clinical entities. Recent Findings Pediatric-type ALL chemotherapy regimens, compared to both lymphoma-type chemotherapy and adult-type ALL regimens, have led to improved outcomes for children, adolescents, and young adults with ALL. BCR-ABL-targeting tyrosine kinase inhibitors (TKIs) have improved outcomes in Philadelphia chromosome-positive (Ph +) ALL and in rare cases of Ph + LBL. Newer therapies including blinatumomab, inotuzumab, CAR-T therapy, and nelarabine have improved outcomes in selected cases of ALL and have an emerging role in the management of LBL. Better understanding of ALL and LBL biology allows for the development of therapies that target immunophenotypic or genetic features found in subsets of both diseases. Novel therapies are leading to improved outcomes in Ph + and relapsed and refractory disease.
引用
收藏
页码:384 / 393
页数:10
相关论文
共 99 条
[1]   Prognostic Factors and Outcomes of Adult Lymphoblastic Lymphoma in the United States [J].
Abd El-Fattah, Mohamed .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 (08) :498-+
[2]   Results of SWOG 1318: A Phase 2 Trial of Blinatumomab Followed By Pomp (Prednisone, Vincristine, Methotrexate, 6-Mercaptopurine) Maintenance in Elderly Patients with Newly Diagnosed Philadelphia Chromosome Negative B-Cell Acute Lymphoblastic Leukemia [J].
Advani, Anjali S. ;
Moseley, Anna ;
O'Dwyer, Kristen Marie ;
Wood, Brent ;
Fang, Min ;
Wieduwilt, Matthew J. ;
Aldoss, Ibrahim ;
Park, Jae H. ;
Klisovic, Rebecca ;
Baer, Maria R. ;
Stock, Wendy ;
Bhave, Rupali ;
Othus, Megan ;
Litzow, Mark R. ;
Stone, Richard M. ;
Erba, Harry P. .
BLOOD, 2018, 132
[3]   NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study [J].
Asnafi, Vahid ;
Buzyn, Agnes ;
Le Noir, Sandrine ;
Baleydier, Frederic ;
Simon, Arnauld ;
Beldjord, Kheira ;
Reman, Oumedaly ;
Witz, Francis ;
Fagot, Thierry ;
Tavernier, Emmanuelle ;
Turlure, Pascal ;
Leguay, Thibaut ;
Huguet, Francoise ;
Vernant, Jean-Paul ;
Daniel, Francis ;
Bene, Marie-Christine ;
Ifrah, Norbert ;
Thomas, Xavier ;
Dombret, Herve ;
Macintyre, Elizabeth .
BLOOD, 2009, 113 (17) :3918-3924
[4]   Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents [J].
Attarbaschi, Andishe ;
Carraro, Elisa ;
Abla, Oussama ;
Barzilai-Birenboim, Shlomit ;
Bomken, Simon ;
Brugieres, Laurence ;
Bubanska, Eva ;
Burkhardt, Birgit ;
Chiang, Alan K. S. ;
Csoka, Monika ;
Fedorova, Alina ;
Jazbec, Janez ;
Kabickova, Edita ;
Krenova, Zdenka ;
Lazic, Jelena ;
Fen, Jan Loef ;
Mann, Georg ;
Niggli, Felix ;
Miakova, Natalia ;
Osumi, Tomoo ;
Ronceray, Leila ;
Uyttebroeck, Anne ;
Williams, Denise ;
Woessmann, Wilhelm ;
Wrobel, Grazyna ;
Pillon, Marta .
HAEMATOLOGICA, 2016, 101 (12) :1581-1591
[5]   Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma [J].
Aujla, Amandeep ;
Aujla, Ravijot ;
Liu, Delong .
BIOMARKER RESEARCH, 2019, 7 (1)
[6]   Proposal of a genetic classifier for risk group stratification in pediatric T-cell lymphoblastic lymphoma reveals differences from adult T-cell lymphoblastic leukemia [J].
Balbach, S. T. ;
Makarova, O. ;
Bonn, B. R. ;
Zimmermann, M. ;
Oschlies, I. ;
Klapper, W. ;
Roessig, C. ;
Burkhardt, B. .
LEUKEMIA, 2016, 30 (04) :970-973
[7]   Lymphoblastic lymphoma: an updated review on biology, diagnosis, and treatment [J].
Bassan, Renato ;
Maino, Elena ;
Cortelazzo, Sergio .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2016, 96 (05) :447-460
[8]   T-Cell Lymphoblastic Lymphoma Shows Differences and Similarities with T-Cell Acute Lymphoblastic Leukemia by Genomic and Gene Expression Analyses [J].
Basso, Katia ;
Mussolin, Lara ;
Lettieri, Antonella ;
Brahmachary, Manisha ;
Lim, Wei Keat ;
Califano, Andrea ;
Basso, Giuseppe ;
Biondi, Andrea ;
Cazzaniga, Giovanni ;
Rosolen, Angelo .
GENES CHROMOSOMES & CANCER, 2011, 50 (12) :1063-1075
[9]   Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-Cell malignancies: A report from the children's oncology group [J].
Berg, SL ;
Blaney, SM ;
Devidas, M ;
Lampkin, TA ;
Murgo, A ;
Bernstein, M ;
Billett, A ;
Kurtzberg, J ;
Reaman, G ;
Gaynon, P ;
Whitlock, J ;
Krailo, M ;
Harris, MB .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (15) :3376-3382
[10]   Multimodal treatment with ALL-like chemotherapy, Auto-SCT and radiotherapy for lymphoblastic lymphoma [J].
Bersvendsen, Hanne ;
Kolstad, Arne ;
Blystad, Anne Kirsti ;
Aurlien, Ellen ;
Fossa, Alexander ;
Kvaloy, Stein O. ;
Holte, Harald ;
Lauritzsen, Grete F. .
ACTA ONCOLOGICA, 2014, 53 (05) :680-687