Intramolecular, Visible-Light-Mediated Aza Paterno-Buchi Reactions of Unactivated Alkenes

被引：29

作者：

Blackmun, Dominique E. ^{[1
]}

Chamness, Stephen A. . ^{[1
]}

Schindler, Corinna S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Willard Henry Dow Lab, Ann Arbor, MI 48109 USA

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 16期

关键词：

AZETIDINES;

D O I：

10.1021/acs.orglett.2c01008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Azetidines are of particular interest in medicinal chemistry for their favorable properties, including increased resistance to oxidative metabolism and lower lipophilicity. The recent development of [2 + 2] reactions has significantly expanded the limited repertoire of methods for azetidine synthesis, but access to more complex architectures still requires further development. Herein, we report a visible-light-enabled intramolecular [2 + 2] cycloaddition of unactivated alkenes that proved previously unreactive to access tricyclic azetidines with 3D complex structures and high levels of saturation.

引用

页码：3053 / 3057

页数：5

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