Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

被引：9

作者：

Marutescu, Luminita ^{[1
,2
]}

Calu, Larisa ^{[3
]}

Chifiriuc, Mariana Carmen ^{[1
,2
]}

Bleotu, Coralia ^{[4
]}

Daniliuc, Constantin-Gabriel ^{[5
]}

Falcescu, Denisa ^{[3
]}

Kamerzan, Crina Maria ^{[1
,2
]}

Badea, Mihaela ^{[3
]}

Olar, Rodica ^{[3
]}

机构：

[1] Univ Bucharest, Fac Biol, Dept Microbiol, 1-3 Aleea Portocalelor Str, Bucharest 60101, Romania

[2] Univ Bucharest ICUB, Res Inst, Environm & Earth Sci Dept, Life, Spl Independentei 91-95, Bucharest 010271, Romania

[3] Univ Bucharest, Fac Chem, Dept Inorgan Chem, 90-92 Panduri Str, Bucharest 050663, Romania

[4] Stefan S Nicolau Inst Virol, 285 Mihai Bravu Ave, Bucharest 030304, Romania

[5] Westfal Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany

来源：

MOLECULES | 2017年 / 22卷 / 07期

关键词：

Co(II) complex; 1,2,4-triazolo[1,5-a]pyrimidine; cis-disposition; biofilm; cytotoxicity; IN-VITRO; PLATINUM(II) COMPLEXES; SPECTROSCOPIC CHARACTERIZATION; ORGANOTIN(IV) DERIVATIVES; AGENTS; COBALT(II); LIGAND; HETEROCYCLES; CYTOTOXICITY; ELUCIDATION;

D O I：

10.3390/molecules22071233

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three complexes, namely [Co(dmtp)(2)(OH2)(4)][CoCl4] (1),[Co(dmtp)(2)Cl-2] (2) and [Co(dmtp)(2)(OH2)(4)]Cl-2 center dot 2H(2)O (3) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (1) crystallizes in monoclinic system (space group C2/c), complex (2) adopts an orthorhombic system (space group Pbca), and complex (3) crystallizes in triclinic system (space group P (1) over bar). Various types of extended hydrogen bonds and pi-pi interactions provide a supramolecular architecture for all complexes. All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression.

引用

页数：19

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