Animal Models of Retinal Injury

被引：32

作者：

Blanch, Richard J. ^{[1
,2
]}

Ahmed, Zubair

Berry, Martin

Scott, Robert A. H. ^{[2
,3
,4
]}

Logan, Ann ^{[3
,4
]}

机构：

[1] Univ Birmingham, Sch Med, Mol Neurosci Res Grp, Neuropharmacol & Neurobiol Sect, Birmingham B15 2TT, W Midlands, England

[2] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England

[3] Natl Inst Hlth Res Surg Reconstruct, Birmingham, W Midlands, England

[4] Microbiol Res Ctr, Birmingham, W Midlands, England

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2012年 / 53卷 / 06期

关键词：

OPTIC-NERVE REGENERATION; COMBINED POSTERIOR CONTUSION; GANGLION-CELLS; IN-VIVO; PIGMENT EPITHELIUM; RAT RETINA; AXONAL REGENERATION; GENE-EXPRESSION; OCULAR TRAUMA; GROWTH-FACTOR;

D O I：

10.1167/iovs.11-8564

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Retinal injury is a common cause of profound and intractable loss of vision. Clinical outcomes are poor in both open and closed globe injuries because cell death, scarring, and a failure of tissue and axon regeneration are not ameliorated by current treatments. Much animal research is directed at understanding and modifying these pathologies, although results have yet to translate into clinical practice. Axotomy-induced retinal ganglion cell (RGC) death in mammals can be effectively reduced and axon regeneration enhanced over the short term. After retinal injury in mammals, the retinal pigment epithelium (RPE) and retinal glia either regenerate lost RPE and neuroretinal cells or form nonfunctional scars. An understanding of the mechanisms underlying injury responses is critical to the successful development of therapeutic strategies to promote ocular repair. (Invest Ophthalmol Vis Sci. 2012; 53: 2913-2920) DOI: 10.1167/iovs.11-8564

引用

页码：2913 / 2920

页数：8

共 103 条

[1] In vivo models of proliferative vitreoretinopathy [J].

Agrawal, Rajat N. ;

He, Shikun ;

Spee, Christine ;

Cui, Jing Z. ;

Ryan, Stephen J. ;

Hinton, David R. .

NATURE PROTOCOLS, 2007, 2 (01) :67-77

[2] Ocular neuroprotection by siRNA targeting caspase-2 [J].

Ahmed, Z. ;

Kalinski, H. ;

Berry, M. ;

Almasieh, M. ;

Ashush, H. ;

Slager, N. ;

Brafman, A. ;

Spivak, I. ;

Prasad, N. ;

Mett, I. ;

Shalom, E. ;

Alpert, E. ;

Di Polo, A. ;

Feinstein, E. ;

Logan, A. .

CELL DEATH & DISEASE, 2011, 2 :e173-e173

[3] Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic [J].

Ahmed, Zubair ;

Aslam, Mudasser ;

Lorber, Barbara ;

Suggate, Ellen L. ;

Berry, Martin ;

Logan, Ann .

NEUROBIOLOGY OF DISEASE, 2010, 37 (02) :441-454

[4]

Al-Hussaini H, 2008, MOL VIS, V14, P1784

[5] The murine cone photoreceptor: A single cone type expresses both S and M opsins with retinal spatial patterning [J].

Applebury, ML ;

Antoch, MP ;

Baxter, LC ;

Chun, LLY ;

Falk, JD ;

Farhangfar, F ;

Kage, K ;

Krzystolik, MG ;

Lyass, LA ;

Robbins, JT .

NEURON, 2000, 27 (03) :513-523

[6]

Becker CG, 2008, RESTOR NEUROL NEUROS, V26, P71

[7] Optic Nerve Regeneration [J].

Benowitz, Larry I. ;

Yin, Yuqin .

ARCHIVES OF OPHTHALMOLOGY, 2010, 128 (08) :1059-1064

[8] AXOTOMY RESULTS IN DELAYED DEATH AND APOPTOSIS OF RETINAL GANGLION-CELLS IN ADULT-RATS [J].

BERKELAAR, M ;

CLARKE, DB ;

WANG, YC ;

BRAY, GM ;

AGUAYO, AJ .

JOURNAL OF NEUROSCIENCE, 1994, 14 (07) :4368-4374

[9]

Berry M, 2008, RESTOR NEUROL NEUROS, V26, P147

[10] Inhibition of Retinal Detachment-Induced Apoptosis in Photoreceptors by a Small Peptide Inhibitor of the Fas Receptor [J].

Besirli, Cagri G. ;

Chinskey, Nicholas D. ;

Zheng, Qiong-Duan ;

Zacks, David N. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (04) :2177-2184

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