AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study

被引:76
作者
Liu, Yongmei [1 ]
Zhao, Peiling [1 ]
Cheng, Mingliang [1 ]
Yu, Lei [2 ]
Cheng, Zhuo [3 ]
Fan, Linda [1 ]
Chen, Chi [4 ]
机构
[1] Guizhou Med Univ, Dept Infect Dis, Affiliated Hosp, 28 Guiyi Rd, Guiyang 550004, Guizhou, Peoples R China
[2] Guizhou Med Univ, Prenatal Diag Ctr, 2 Beijing Rd, Guiyang 550004, Guizhou, Peoples R China
[3] Peking Univ, Hlth Sci Ctr, Dept Clin Med, Beijing 100191, Peoples R China
[4] Guiyang Coll Tradit Chinese Med, Dept Immunol & Microbiol, 84 ShiDong Rd, Guiyang 550001, Guizhou, Peoples R China
关键词
Aspartate aminotransferase; Alanine aminotransferase; Brachial-ankle pulse wave velocity; Association; PULSE-WAVE VELOCITY; BRACHIAL-ANKLE; RISK; DISEASE;
D O I
10.1186/s12944-018-0920-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
BackgroundPrevious studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of the major risk factors for cardiovascular disease, insulin resistance and metabolism syndrome. However, there are fewer investigations of the correlations between the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio and brachial ankle pulse wave velocity (baPWV). This study was undertaken to investigate the relationship between the AST to ALT ratio and brachial-ankle pulse wave velocity (baPWV) in a Japanese population.MethodsThe present study was a cross-sectional study. A total of 646 Japanese men and women without fatty liver, aged 2484years old, received a health medical check-up programme including the results from baPWV inspection and various standardized questionnaires in a health examination centre in Japan. Main outcome measures included AST/ALT ratio, baPWV, fatty liver and postmenopausal status. Abdominal ultrasonography was used to diagnose fatty liver. A postmenopausal state was defined as beginning 1year following the cessation of menses.ResultsAfter adjusting for potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise statuses, fatty liver, alcohol consumption and ABI), a non-linear relationship was detected between AST/ALT and baPWV, which had an inflection point of 5.6. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 12.7 (1.9 to 23.5) and-16.7 (-36.8 to 3.3), respectively. Subgroup analysis in participants with excessive alcohol consumption (more than 280g/week) showed that AST/ALT had a negative correlation with baPWV (=-30.7, 95%CI (-53.1, -8.4)), and the P value for the interaction was less than 0.05.ConclusionThe relationship between AST/ALT and baPWV is non-linear. AST/ALT was positively correlated with baPWV when AST/ALT was less than 5.6. In addition, the trend was the opposite in subjects who consumed excessive amounts of alcohol.
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相关论文
共 16 条
  • [1] Botros Mona, 2013, Clin Biochem Rev, V34, P117
  • [2] Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study
    Fukuda, Takuya
    Hamaguchi, Masahide
    Kojima, Takao
    Ohshima, Yasuhiro
    Ohbora, Akihiro
    Kato, Takahiro
    Nakamura, Naoto
    Fukui, Michiaki
    [J]. BMJ OPEN, 2014, 4 (10):
  • [3] De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
    Gao, Fan
    Chen, Chen
    Lu, Jun
    Zheng, Jie
    Ma, Xian-Cang
    Yuan, Xing-Yun
    Huo, Kang
    Han, Jian-Feng
    [J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2017, 13 : 1551 - 1557
  • [4] Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study
    Katsiki, Niki
    Kollari, Erietta
    Dardas, Sotirios
    Dardas, Petros
    Haidich, Anna-Bettina
    Athyros, Vasilios G.
    Karagiannis, Asterios
    [J]. OPEN CARDIOVASCULAR MEDICINE JOURNAL, 2016, 10 : 64 - 68
  • [5] Phenylpropanolamine and the risk of hemorrhagic stroke.
    Kernan, WN
    Viscoli, CM
    Brass, LM
    Broderick, JP
    Brott, T
    Feldmann, E
    Morgenstern, LB
    Wilterdink, JL
    Horwitz, RI
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (25) : 1826 - 1832
  • [6] Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease
    Kim, SG
    Kim, HY
    Seo, JA
    Lee, KW
    Oh, JH
    Kim, NH
    Choi, KM
    Baik, SH
    Choi, DS
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 152 (02) : 225 - 231
  • [7] Which Liver Enzymes Are Better Indicators of Metabolic Syndrome in Adolescents: The Fifth Korea National Health and Nutrition Examination Survey, 2010
    Lee, Kayoung
    Yang, Jin Hyang
    [J]. METABOLIC SYNDROME AND RELATED DISORDERS, 2013, 11 (04) : 229 - 235
  • [8] Sex and Race (Black-White) Differences in the Relationship of Childhood Risk Factors to Adulthood Arterial Stiffness: The Bogalusa Heart Study
    Li, Shengxu
    Chen, Wei
    Yun, Miaoying
    Fernandez, Camilo
    Krousel-Wood, Marie
    Webber, Larry
    Srinivasan, Sathanur R.
    Berenson, Gerald S.
    [J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2014, 348 (02) : 101 - 107
  • [9] The effects of intraoperative cryoprecipitate transfusion on acute renal failure following orthotropic liver transplantation
    Liu, Shuang
    Wang, Xiaoliang
    Lu, Yuanshan
    Li, Tao
    Gong, Zijun
    Sheng, Tao
    Hu, Bin
    Peng, Zhihai
    Sun, Xing
    [J]. HEPATOLOGY INTERNATIONAL, 2013, 7 (03) : 901 - 909
  • [10] Ohkuma T, 2017, HYPERTENSION, V69, P1045, DOI [10.1161/HYPERTENSIONAHA.117.09097, 10.1161/hypertensionaha.117.09097]