The effects of ApoE gene polymorphisms on lumbar spine bone mineral density and carotid atherosclerosis

被引：2
作者：
Hou, Jianming [1 ]
Wu, Huinan [2 ]
机构：
[1] Fujian Med Univ, Prov Hosp Fujian, Prov Clin Coll, Dept Endocrinol, Fuzhou 350001, Peoples R China
[2] Fujian Med Univ, Shishi Hosp, Teaching Hosp, Dept Endocrinol, Quanzhou 362700, Peoples R China
来源：
CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 03期
关键词：
Osteoporosis; Carotid atherosclerosis; Apolipoprotein E; Gene polymorphism; APOLIPOPROTEIN-E POLYMORPHISM; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; FRACTURE RISK; OSTEOPOROSIS; ASSOCIATION; FEMALES; MEN; HIP; BMD;
D O I：
10.1016/j.clinbiochem.2011.11.014
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objectives: We analyzed the correlation between osteoporosis and carotid atherosclerosis (CA) by exploring the effects of ApoE gene polymorphisms on bone mineral density (BMD) of the lumbar spine and CA. Design and methods: We selected 221 elderly Han male patients and divided them into four groups: control, CA, BMD down arrow, and CA+BMD down arrow according to their carotid ultrasonography and lumbar BMD results. ApoE gene polymorphisms were examined in each group. Results: The CA group had a higher incidence of ApoE4 isoforms compared to normal controls (P<0.05). The ApoE4 isoform incidence in the BMD down arrow, and BMD down arrow/CA groups showed no significant difference from control. ApoE4 genotype incidences in the CA group, BMD down arrow group, and CA/BMD down arrow group were not significantly different. Conclusion: The ApoE4 genotype may be a risk factor for carotid atherosclerosis, but is not correlated with bone mineral density (BMD) in the lumbar spine in elderly Han males. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：219 / 222
页数：4
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