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Review of the Ocular Angiogenesis Animal Models
被引:53
作者:
Montezuma, Sandra R.
[1
]
Vavvas, Demetrios
[1
]
Miller, Joan W.
[1
]
机构:
[1] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Retina Serv,Dept Ophthalmol, Boston, MA 02114 USA
关键词:
angiogenesis;
choroidal neovascularization (CNV);
corneal neovascularization;
subretinal neovascularization (SRN);
Basic Fibroblast Growth Factor (bFGF);
Vascular Endothelial Growth Factor (VEGF);
fluorescein angiography (FA);
BALB C and C57BL-6 mice;
knockout or knock-in transgenic mice;
ENDOTHELIAL GROWTH-FACTOR;
EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION;
OXYGEN-INDUCED RETINOPATHY;
EXPERIMENTAL SUBRETINAL NEOVASCULARIZATION;
EXPERIMENTAL PRERETINAL NEOVASCULARIZATION;
ARGON-LASER PHOTOCOAGULATION;
VASCULAR-PERMEABILITY FACTOR;
CORNEAL NEOVASCULARIZATION;
RETINAL NEOVASCULARIZATION;
PROLIFERATIVE RETINOPATHY;
D O I:
10.1080/08820530902800017
中图分类号:
R77 [眼科学];
学科分类号:
100212 ;
摘要:
Increasing interest in developing reliable and reproducible models to study angiogenesis has emerged due to recent advances in the treatment of eye disease with pathologic angiogenesis. This review provides a summary of the principal ocular animal models for angiogenesis. Models of anterior segment neovascularization include the corneal micropocket assay, used to study the influence of specific molecules/proteins in angiogenesis, and corneal chemical and suture induced injury, which mimic more closely the complex nature of the human disease. Angiogenesis models of the posterior segment include the well-known laser-induced injury of the choroid/Bruch's membrane, as well as the oxygen induced retinopathy and models of injections of pro-angiogenic/inflammatory molecules. In addition, knockout or knock-in transgenic mice provide powerful tools in studying the role of specific proteins in angiogenesis.
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页码:52 / 61
页数:10
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