Review of the Ocular Angiogenesis Animal Models

被引:53
作者
Montezuma, Sandra R. [1 ]
Vavvas, Demetrios [1 ]
Miller, Joan W. [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Retina Serv,Dept Ophthalmol, Boston, MA 02114 USA
关键词
angiogenesis; choroidal neovascularization (CNV); corneal neovascularization; subretinal neovascularization (SRN); Basic Fibroblast Growth Factor (bFGF); Vascular Endothelial Growth Factor (VEGF); fluorescein angiography (FA); BALB C and C57BL-6 mice; knockout or knock-in transgenic mice; ENDOTHELIAL GROWTH-FACTOR; EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION; OXYGEN-INDUCED RETINOPATHY; EXPERIMENTAL SUBRETINAL NEOVASCULARIZATION; EXPERIMENTAL PRERETINAL NEOVASCULARIZATION; ARGON-LASER PHOTOCOAGULATION; VASCULAR-PERMEABILITY FACTOR; CORNEAL NEOVASCULARIZATION; RETINAL NEOVASCULARIZATION; PROLIFERATIVE RETINOPATHY;
D O I
10.1080/08820530902800017
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Increasing interest in developing reliable and reproducible models to study angiogenesis has emerged due to recent advances in the treatment of eye disease with pathologic angiogenesis. This review provides a summary of the principal ocular animal models for angiogenesis. Models of anterior segment neovascularization include the corneal micropocket assay, used to study the influence of specific molecules/proteins in angiogenesis, and corneal chemical and suture induced injury, which mimic more closely the complex nature of the human disease. Angiogenesis models of the posterior segment include the well-known laser-induced injury of the choroid/Bruch's membrane, as well as the oxygen induced retinopathy and models of injections of pro-angiogenic/inflammatory molecules. In addition, knockout or knock-in transgenic mice provide powerful tools in studying the role of specific proteins in angiogenesis.
引用
收藏
页码:52 / 61
页数:10
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