Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning From Nature

被引:12
作者
Ghaani, Mohammad Reza [1 ]
Allen, Christopher C. R. [2 ]
Skvortsov, Timofey [3 ]
English, Niall J. [1 ]
机构
[1] Univ Coll Dublin, Sch Chem & Bioproc Engn, Dublin 4, Ireland
[2] Queens Univ Belfast, Sch Biol Sci, Belfast BT9 5DL, Antrim, North Ireland
[3] Queens Univ Belfast, Sch Pharm, Belfast BT7 1NN, Antrim, North Ireland
基金
爱尔兰科学基金会;
关键词
AMINO-ACIDS; ANTIFREEZE PROTEINS; WATER; INHIBITION; CLATHRATE; KINETICS; GROWTH; SALINE; MODEL; ICE;
D O I
10.1021/acs.jpclett.0c01224
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Clathrate hydrates are nonstoichiometric crystalline inclusion compounds. Water acts as a "host lattice" and traps small guest molecules in stable cavities. One example, methane hydrates, are especially prevalent in situ at the seafloor. Although microorganism-produced proteins and polypeptides, including marine methylotroph porin proteins, can accelerate methane hydrate formation under conditions simulating their natural occurrence at the seafloor, the role that particular peptide sequences play in biocatalytic hydrate kinetics enhancement is unclear, especially the underlying molecular-level mechanisms. Here, we reveal the peptide-focused regulation of microorganisms' role in managing marine hydrates via an approximation mechanism of enzymatic catalysis accelerating hydrate formation. Aside from control of hydrate kinetics per se, we speculate that this peptide-centric mechanistic understanding could lead to a re-evaluation of the extent and geological importance of bioregulation of methane turnover in the biosphere.
引用
收藏
页码:5068 / 5075
页数:8
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