MICRORNA AND VASCULAR SMOOTH MUSCLE CELLS

被引：14
|
作者：
Xie, Changqing [1 ]
Zhang, Jifeng [1 ]
Chen, Y. Eugene [1 ]
机构：
[1] Univ Michigan, Med Ctr, Dept Internal Med, Ctr Cardiovasc, Ann Arbor, MI 48109 USA
来源：
VITAMINS AND HORMONES: STEM CELL REGULATORS | 2011年 / 87卷
关键词：
SERUM RESPONSE FACTOR; RECEPTOR GENE POLYMORPHISMS; NEOINTIMAL LESION FORMATION; EXPRESSION IN-VIVO; ANGIOTENSIN-II; TRANSCRIPTION FACTORS; MESSENGER-RNAS; NUCLEAR EXPORT; DIFFERENTIATION MARKERS; MICROPROCESSOR COMPLEX;
D O I：
10.1016/B978-0-12-386015-6.00034-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vascular smooth muscle cells (VSMCs) exhibit extraordinary plasticity during postnatal development. Vascular injury initiates VSMC phenotypic switch from the contractile to proliferative phenotype, which plays a central role in vascular lesion formation and diverse vascular diseases. MicroRNAs (miRNAs) regulate gene expression posttranscriptionally by either degrading target mRNAs or repressing their translation. Emerging evidence has revealed miRNAs are critical regulators in VSMC differentiation from stem cells, phenotypic switch, and various vascular pathogenesis. Here, we review recent advances regarding functions of specific miRNAs in vasculature and discuss possible mechanisms by which miRNAs affect VSMC biology. (C) 2011 Elsevier Inc.
引用
收藏
页码：321 / 339
页数：19
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