Macrocyclic lactone resistance in Dirofilaria immitis

被引：71

作者：

Bourguinat, Catherine ^{[1
]}

Keller, Kathy ^{[1
]}

Bhan, Aron ^{[2
]}

Peregrine, Andrew ^{[3
]}

Geary, Timothy ^{[1
]}

Prichard, Roger ^{[1
]}

机构：

[1] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X3V9, Canada

[2] Main W Anim Hosp, Welland, ON L3C5L2, Canada

[3] Univ Guelph, Ontario Vet Coll, Guelph, ON N1G 2W1, Canada

来源：

VETERINARY PARASITOLOGY | 2011年 / 181卷 / 2-4期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Dirofilaria immitis; Heartworm; Macrocyclic lactone; Heartworm preventative; Anthelmintic resistance; Ivermectin; ONCHOCERCA-VOLVULUS; IVERMECTIN RESISTANCE; DRUG-RESISTANCE; PARASCARIS-EQUORUM; HEARTWORM; EFFICACY; INFECTION; SELECTION; NEMATODES; MARKER;

D O I：

10.1016/j.vetpar.2011.04.012

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Microfilariae were isolated from a Katrina rescue dog that remained microfilariaemic despite successful adulticidal treatments and repeated treatment with high doses of macrocyclic lactones (MLs). The microfilariae were genotyped at two P-glycoprotein single nucleotide polymorphic sites which had been found to correlate with reduced sensitivity to MLs. The genetic polymorphism (GG-GG), previously found to be associated with insensitivity to MLs in vitro, was present at a frequency of 45.3% in microfilariae that survived repeated treatments with high doses of ML anthelmintics. The data show phenotypic and genotypic evidence of ML resistance in Dirofilaria immitis. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：388 / 392

页数：5

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