Design of barrier coatings on kink-resistant peripheral nerve conduits

被引:44
|
作者
Clements, Basak Acan [1 ]
Bushman, Jared [2 ]
Murthy, N. Sanjeeva [1 ]
Ezra, Mindy [1 ]
Pastore, Christopher M. [3 ]
Kohn, Joachim [1 ,4 ]
机构
[1] Rutgers State Univ, New Jersey Ctr Biomat, 145 Bevier Rd, Piscataway, NJ 08854 USA
[2] Univ Wyoming, Sch Pharm, Laramie, WY USA
[3] Philadelphia Univ, Kanbar Coll Design Engn & Commerce, Philadelphia, PA USA
[4] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ USA
来源
JOURNAL OF TISSUE ENGINEERING | 2016年 / 7卷
关键词
Peripheral nerve; nerve regeneration; nerve conduit; braided conduit; braiding; porosity; hyaluronic acid; TYROSINE-DERIVED POLYCARBONATES; ACID-COLLAGEN TUBE; POLYGLYCOLIC ACID; ELECTROPHYSIOLOGICAL EVALUATION; GUIDE TUBE; IN-VITRO; REGENERATION; REPAIR; BIOMATERIALS; GAP;
D O I
10.1177/2041731416629471
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of the conduit. This problem can be controlled by the application of secondary barrier coatings. Using a critical size defect in a rat sciatic nerve model, the importance of controlling the porosity of the nerve conduit walls was explored. Braided conduits without barrier coatings allowed cellular infiltration that limited nerve recovery. Several types of secondary barrier coatings were tested in animal studies, including ( 1) electrospinning a layer of polymer fibers onto the surface of the conduit and ( 2) coating the conduit with a cross-linked hyaluronic acid-based hydrogel. Sixteen weeks after implantation, hyaluronic acid-coated conduits had higher axonal density, displayed higher muscle weight, and better electrophysiological signal recovery than uncoated conduits or conduits having an electrospun layer of polymer fibers. This study indicates that braiding is a promising method of fabrication to improve the mechanical properties of peripheral nerve conduits and demonstrates the need to control the porosity of the conduit wall to optimize functional nerve recovery.
引用
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页数:14
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