Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support

被引：40

作者：

Shields, Alexandra E. ^{[1
,2
]}

Wise, Lauren A. ^{[3
,4
]}

Ruiz-Narvaez, Edward A. ^{[3
,4
]}

Seddighzadeh, Bobak ^{[2
]}

Byun, Hyang-Min ^{[5
]}

Cozier, Yvette C. ^{[3
,4
]}

Rosenberg, Lynn ^{[3
,4
]}

Palmer, Julie R. ^{[3
,4
]}

Baccarelli, Andrea A. ^{[2
,6
]}

机构：

[1] Harvard Med Sch, 25 Shattuck St, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Harvard MGH Ctr Genom Vulnerable Populat & Hlth D, 50 Staniford St,Suite 901, Boston, MA 02114 USA

[3] Boston Univ, Sch Publ Hlth, Talbot Bldg,715 Albany St, Boston, MA 02118 USA

[4] Boston Univ, Slone Epidemiol Ctr, 1010 Commonwealth Ave, Boston, MA 02215 USA

[5] Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[6] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, 722 W 168th St, New York, NY 10032 USA

来源：

EPIGENOMICS | 2016年 / 8卷 / 11期

关键词：

abuse; African-Americans; child maltreatment; CpG island shore; DNA methylation; epigenetic epidemiology; glucocorticoid receptor; health disparities; NR3C1; violence; GLUCOCORTICOID-RECEPTOR GENE; BORDERLINE PERSONALITY-DISORDER; CPG ISLAND SHORES; DNA METHYLATION; ADULT-ONSET; RISK; ASSOCIATIONS; HYPERMETHYLATION; MALTREATMENT; SEVERITY;

D O I：

10.2217/epi-2016-0074

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. Materials & methods: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. Results: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. Conclusion: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.

引用

页码：1507 / 1517

页数：11

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