An Efficient Synthesis of 4-Aryl-1,4-dihydropyridines Via VB1 Catalyzed Hantzsch Reaction

被引：2

作者：

Fan, Chuangang ^{[1
]}

Song, Mingzhi ^{[1
]}

机构：

[1] Binzhou Univ, Coll Chem & Chem Technol, Binzhou 256600, Shandong, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2011年 / 8卷 / 10期

关键词：

4-Aryl-1,4-dihydropyridines; VB1; SOLID-PHASE SYNTHESIS; ONE-POT SYNTHESIS; 1,4-DIHYDROPYRIDINES; CONDENSATION; DERIVATIVES;

D O I：

10.2174/157017811799304133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally rapid and benign protocol for the synthesis of 4-aryl-1,4-dihydropyridines compounds using VB1 as a catalyst under microwave irradiation and solvent-free conditions has been achieved. The procedure is operationally simple, giving good to high product yield.

引用

页码：707 / 711

页数：5

共 16 条

[1]

BOCKER RH, 1986, J MED CHEM, V29, P1596

[2] Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation [J].

Breitenbucher, JG ;

Figliozzi, G .

TETRAHEDRON LETTERS, 2000, 41 (22) :4311-4315

[3]

Cai XH, 2005, CHINESE J ORG CHEM, V25, P930

[4] 1,4-DIHYDROPYRIDINES AS ANTAGONISTS OF PLATELET-ACTIVATING-FACTOR .1. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-(4-HETEROCYCLYL)PHENYL DERIVATIVES [J].

COOPER, K ;

FRAY, MJ ;

PARRY, MJ ;

RICHARDSON, K ;

STEELE, J .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (17) :3115-3129

[5] An efficient one-step synthesis of 1,4-dihydropyridines via a triphenylphosphine-catalyzed three-component Hantzsch reaction under mild conditions [J].

Debache, Abdelmadjid ;

Ghalem, Wassima ;

Boulcina, Raouf ;

Belfaitah, Ali ;

Rhouati, Salah ;

Carboni, Bertrand .

TETRAHEDRON LETTERS, 2009, 50 (37) :5248-5250

[6] Approaches to combinatorial synthesis of heterocycles: A solid-phase synthesis of 1,4-dihydropyridines [J].

Gordeev, MF ;

Patel, DV ;

Gordon, EM .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (03) :924-928

[7] Diethyl 4-[4-(dimethylamino)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate [J].

Ji, Xiao-Ling ;

Sun, Wang-Bin ;

Zhang, Qian ;

Cao, Yan-Ping ;

Bai, Ming-Sheng .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 :O519-U4137

[8] Synthesis and biological evaluation of some new 1,4-dihydropyridines containing different ester substitute and diethyl carbamoyl group as anti-tubercular agents [J].

Khoshneviszadeh, Mehdi ;

Edraki, Najmeh ;

Javidnia, Katayoun ;

Alborzi, Abdolvahab ;

Pourabbas, Bahman ;

Mardaneh, Jalal ;

Miri, Ramin .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (04) :1579-1586

[9] VB1-Al2O3-catalyzed one-pot condensation of aromatic ketone, aromatic aldehyde, and amide [J].

Lei, Min ;

Ma, Lei ;

Hu, Lihong .

TETRAHEDRON LETTERS, 2010, 51 (36) :4746-4749

[10] A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst [J].

Lei, Min ;

Ma, Lei ;

Hu, Lihong .

TETRAHEDRON LETTERS, 2010, 51 (32) :4186-4188

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