Babesia:: The protective effects of killed Propionibacterium acnes on the infections of two rodent Babesia parasites in mice

被引：3
作者：
Iseki, Hiroshi [1 ]
Takabatake, Noriyuki [1 ]
Ota, Naomi [1 ]
Ishigame, Takashi [1 ]
Yokoyama, Naoaki [1 ]
Igarashi, Ikuo [1 ]
机构：
[1] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan
来源：
EXPERIMENTAL PARASITOLOGY | 2008年 / 118卷 / 04期
基金：
日本学术振兴会;
关键词：
P; acnes; propionibacterium acnes; B; microti; babesia microti; rodhaini; babesia rodhaini; TNF-alpha; tumor necrosis factor; IFN-gamma; interferon; IL; interleukin; cytokine; mice;
D O I：
10.1016/j.exppara.2007.11.006
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
In the present study, we investigated the protective effects of killed Propionibacterium acnes on the infections of two rodent Babesia parasites in mice. Pre-treatment with "EqStim" (a commercially available inummostimulant containing killed P. acnes) showed significant resistance to both infections. To elucidate the immunological status in the mice, the concentrations of multiple cytokines were measured in serum collected from infected mice. After B. microti infection, the levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12p70, and tumor necrosis factor (TNF)-alpha in the treated group were significantly lower than in the control group. In contrast, after R rodhaini infection, only IL-12p7O and TNF-alpha were detectable at significantly higher levels in the treated group than in the control group. The present findings indicated the protective effects of killed P. acnes on rodent babesiosis even with different immune responses between the R microti and B. rodhaini infections. Killed P. acnes might be a powerful tool for the control of serious livestock babesiosis. (c) 2007 Elsevier Inc. All rights reserved.
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页码：543 / 548
页数：6
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