Immune-mediated Liver Injury in Hepatitis B Virus Infection

被引：45
作者：
Oh, In Soo [1 ,2 ]
Park, Su-Hyung [3 ]
机构：
[1] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Lab Immunol & Infect Dis, Daejeon 34141, South Korea
[2] Chung Ang Univ, Dept Internal Med, Coll Med, Seoul 06973, South Korea
[3] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Lab Translat Immunol & Vaccinol, 291 Daehak Ro, Daejeon 34141, South Korea
来源：
IMMUNE NETWORK | 2015年 / 15卷 / 04期
关键词：
Hepatitis B Virus; Pathogenesis; Immune response;
D O I：
10.4110/in.2015.15.4.191
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.
引用
收藏
页码：191 / 198
页数：8
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