Copper-catalyzed enantioselective C-H functionalization of indoles with an axially chiral bipyridine ligand

被引：44

作者：

Gao, Xiang ^{[1
,2
]}

Wu, Bo ^{[1
]}

Yan, Zhong ^{[1
]}

Zhou, Yong-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 35期

基金：

中国国家自然科学基金;

关键词：

ALPHA-DIAZOCARBONYL COMPOUNDS; DIAZO-COMPOUNDS; INSERTION REACTIONS; RHODIUM CARBENOIDS; EFFICIENT APPROACH; AMINO-ACIDS; BONDS; DIAZOESTERS; DERIVATIVES; CARBOXYLATES;

D O I：

10.1039/c6ob01516f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using copper complexes with an axially chiral bipyridine ligand C4-ACBP as the catalyst, an enantioselective functionalization of indoles with diazo compounds was developed with up to 95% ee. This protocol paves the way for further applications of these ligands.

引用

页码：8237 / 8240

页数：4

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