Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

被引：8
作者：
Lodise, Thomas P. [1 ]
Scheetz, Marc [2 ]
Carreno, Joseph J. [1 ]
Chambers, Henry [3 ]
Fowler, Vance, Jr. [4 ,5 ]
Holland, Thomas L. [4 ,5 ]
机构：
[1] Albany Coll Pharm & Hlth Sci, 106 Now Scotland Ave, Albany, NY 12208 USA
[2] Midwestern Univ Chicago, Coll Pharm, Chicago, IL USA
[3] San Francisco Gen Hosp, San Francisco, CA USA
[4] Duke Clin Res Inst, Durham, NC USA
[5] Duke Univ, Med Ctr, Durham, NC USA
来源：
OPEN FORUM INFECTIOUS DISEASES | 2022年 / 9卷 / 02期
关键词：
MRSA; outcomes; pharmacokinetics; vancomycin; NEPHROTOXICITY;
D O I：
10.1093/ofid/ofab651
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Among patients with methicillin-resistant Staphylococcus aureus bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400-600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.
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页数：7
相关论文
共 20 条
  • [1] Vancomycin Area Under the Curve and Acute Kidney Injury: A Meta-analysis
    Aljefri, Doaa M.
    Avedissian, Sean N.
    Rhodes, Nathaniel J.
    Postelnick, Michael J.
    Nguyen, Kevin
    Scheetz, Marc H.
    [J]. CLINICAL INFECTIOUS DISEASES, 2019, 69 (11) : 1881 - 1887
  • [2] [Anonymous], 2012, Kidney Int Suppl (2011), V2, P19
  • [3] [Anonymous], GUID IND PHARM PAT I
  • [4] Twenty-four hour pharmacokinetic relationships for intravenous vancomycin and novel urinary biomarkers of acute kidney injury in a rat model
    Avedissian, Sean N.
    Pais, Gwendolyn M.
    O'Donnell, J. Nicholas
    Lodise, Thomas P.
    Liu, Jiajun
    Prozialeck, Walter C.
    Joshi, Medha D.
    Lamar, Peter C.
    Becher, Leighton
    Gulati, Anil
    Hope, William
    Scheetz, Marc H.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 (08) : 2326 - 2334
  • [5] Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Bellomo, R
    Ronco, C
    Kellum, JA
    Mehta, RL
    Palevsky, P
    [J]. CRITICAL CARE, 2004, 8 (04): : R204 - R212
  • [6] Pharmacokinetic/Pharmacodynamic Determinants of Vancomycin Efficacy in Enterococcal Bacteremia
    Bin Jumah, Muhammed Taufiq
    Vasoo, Shawn
    Menon, Sanjay R.
    De, Partha Pratim
    Neely, Michael
    Teng, Christine B.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (03)
  • [7] Chavada R, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.02535-16, 10.1128/aac.02535-16]
  • [8] D'Argenio DZ., 2009, ADAPT 5 User's Guide: Pharmacokinetic/Pharmacodynamic Systems Analysis Software
  • [9] Vancomycin Area Under the Curve-Guided Dosing and Monitoring for Adult and Pediatric Patients With Suspected or Documented Serious Methicillin-Resistant Staphylococcus aureus Infections: Putting the Safety of Our Patients First
    Lodise, Thomas P.
    Drusano, George
    [J]. CLINICAL INFECTIOUS DISEASES, 2021, 72 (09) : 1497 - 1501
  • [10] Gounden V., 2018, Renal function tests
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