Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small "Hit" in Cancer Diagnosis

被引：8
作者：
Alberti, Giusi [1 ]
Sanchez-Lopez, Christian M. [2 ,3 ]
Andres, Alexia [3 ]
Santonocito, Radha [1 ]
Campanella, Claudia [1 ]
Cappello, Francesco [1 ]
Marcilla, Antonio [2 ,3 ]
机构：
[1] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost Bi, I-90127 Palermo, Italy
[2] Univ Valencia, Dept Farm Tecnol Farmaceut Parasitol Farm, Area Parasitol, Burjassot 46100, Spain
[3] Inst Invest SanitariaLa Fe, Joint Unit Endocrinol, Valencia 46026, Spain
来源：
APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 22期
关键词：
extracellular vesicles; liquid biopsy; biomarkers; tumor progression; metastasis; PROTEOMIC ANALYSIS; HEPATOCELLULAR-CARCINOMA; EXOSOMAL PROTEINS; SERUM EXOSOMES; LIQUID BIOPSY; STEM-CELLS; BIOMARKER; METASTASIS; EXPRESSION; BIOLOGY;
D O I：
10.3390/app112210787
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monitorization of cancer progression, and response to treatment. This review aims to explore the biomarkers of cancer cell-derived EVs obtained from liquid biopsies, in order to understand cancer progression and metastatic evolution for early diagnosis and precision therapy.
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页数：27
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