Thermal dose control of ultrasound therapies using MR thermometry images:: An in-vitro phantom study

被引:4
作者
Arora, D [1 ]
Cooley, D [1 ]
Perry, T [1 ]
Guo, JY [1 ]
Parker, D [1 ]
Skliar, M [1 ]
Roemer, R [1 ]
机构
[1] Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA
来源
ACC: Proceedings of the 2005 American Control Conference, Vols 1-7 | 2005年
关键词
D O I
10.1109/ACC.2005.1469969
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
An MR-based thermal treatment controller that delivers a specified thermal dose to a selected target has been developed and evaluated in-vitro using a magnetic resonance (MR) compatible focused ultrasound heating system. The thermal treatment control system has a cascade structure with the main nonlinear dose controller continuously generating the reference temperature trajectory for the secondary constrained, model predictive temperature controller. The control system allows the physician to impose constraints on the maximum allowable temperature elevation at the selected normal tissue location. To reflect hardware imitations and to prevent tissue cavitation, constraint on the maximum transducer power can also be imposed. The combination of a surface coil designed for in-vitro experiments, a gradient echo sequence with k-space reduction and a 3T scanner allowed for fast (1.45s) and low noise (+/- 0.5 degrees C) MR temperature acquisition. The noninvasive thermal images are used during the pre-treatment heating session to characterize the spatial distribution of applied power and effective perfusion, and for the online feedback control of target thermal dose. During the in-vitro phantom experiments the prescribed thermal dose was delivered to the target while restricting the temperature elevation at a selected normal tissue location to below a specified limit. The results demonstrate the robustness of the developed MR-based thermal dose controller in terms of target dose delivery and normal tissue safety.
引用
收藏
页码:405 / 410
页数:6
相关论文
共 18 条
  • [1] PATTERNS OF CHANGES OF TUMOR TEMPERATURES DURING CLINICAL HYPERTHERMIA - IMPLICATIONS FOR TREATMENT PLANNING, EVALUATION AND CONTROL
    ANHALT, DP
    HYNYNEN, K
    ROEMER, RB
    [J]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 1995, 11 (03) : 425 - 436
  • [2] Minimum-time thermal dose control of thermal therapies
    Arora, D
    Skliar, M
    Roemer, RB
    [J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2005, 52 (02) : 191 - 200
  • [3] Arora D, 2004, P AMER CONTR CONF, P1627
  • [4] LOCAL HYPERTHERMIA, RADIATION-THERAPY, AND CHEMOTHERAPY IN PATIENTS WITH LOCAL-REGIONAL RECURRENCE OF BREAST-CARCINOMA
    BORNSTEIN, BA
    ZOURANJIAN, PS
    HANSEN, JL
    FRASER, SM
    GELWAN, LA
    TEICHER, BA
    SVENSSON, GK
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 25 (01): : 79 - 85
  • [5] Optimization of spoiled gradient-echo phase imaging for in vivo localization of a focused ultrasound beam
    Chung, AH
    Hynynen, K
    Colucci, V
    Oshio, K
    Cline, HE
    Jolesz, FA
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) : 745 - 752
  • [6] Dunn F., 1973, Biophysics, V18, P1128
  • [7] GUTHKELCH AN, 1991, J NEURO-ONCOL, V10, P271
  • [8] MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: A feasibility study
    Hynynen, K
    Pomeroy, O
    Smith, DN
    Huber, PE
    McDannold, NJ
    Kettenbach, J
    Baum, J
    Singer, S
    Jolesz, FA
    [J]. RADIOLOGY, 2001, 219 (01) : 176 - 185
  • [9] GENERIC MODEL CONTROL (GMC)
    LEE, PL
    SULLIVAN, GR
    [J]. COMPUTERS & CHEMICAL ENGINEERING, 1988, 12 (06) : 573 - 580
  • [10] MALCOM AL, 2001, ULTRASOUND MED BIOL, V22, P659