Direct and differential effects of stem cell factor on the neovascularization activity of endothelial progenitor cells
被引:36
作者:
Kim, Koung Li
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机构:
Ajou Univ, Coll Pharm, Suwon 443749, South Korea
CHA Univ, Coll Life Sci, Dept Biomed Sci, Pochon Si 487010, Gyeonggi Do, South KoreaAjou Univ, Coll Pharm, Suwon 443749, South Korea
Kim, Koung Li
[1
,2
]
Meng, Yongsun
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机构:
CHA Univ, Coll Life Sci, Dept Biomed Sci, Pochon Si 487010, Gyeonggi Do, South KoreaAjou Univ, Coll Pharm, Suwon 443749, South Korea
Meng, Yongsun
[2
]
Kim, Ji Yeon
论文数: 0引用数: 0
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机构:
Ajou Univ, Coll Pharm, Suwon 443749, South KoreaAjou Univ, Coll Pharm, Suwon 443749, South Korea
Kim, Ji Yeon
[1
]
Baek, Eun Jung
论文数: 0引用数: 0
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机构:
Hanyang Univ, Coll Med, Dept Lab Med, Guri Si 471701, Gyeonggi Do, South KoreaAjou Univ, Coll Pharm, Suwon 443749, South Korea
Baek, Eun Jung
[3
]
Suh, Wonhee
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机构:
Ajou Univ, Coll Pharm, Suwon 443749, South Korea
CHA Univ, Coll Life Sci, Dept Biomed Sci, Pochon Si 487010, Gyeonggi Do, South KoreaAjou Univ, Coll Pharm, Suwon 443749, South Korea
Suh, Wonhee
[1
,2
]
机构:
[1] Ajou Univ, Coll Pharm, Suwon 443749, South Korea
[2] CHA Univ, Coll Life Sci, Dept Biomed Sci, Pochon Si 487010, Gyeonggi Do, South Korea
[3] Hanyang Univ, Coll Med, Dept Lab Med, Guri Si 471701, Gyeonggi Do, South Korea
Aims Previous studies on the role of stem cell factor (SCF) in endothelial progenitor cell (EPC)-mediated neovascularization have focused on the EPC mobilization and homing process. However, the direct effects of SCF on neovascularization activity of EPCs have not been characterized. We sought to determine whether SCF regulates the neovascularization ability of EPCs by comparing its roles in mature endothelial cells. Methods and results In vitro and in vivo assays revealed that SCF substantially increased the neovascularization activity of human EPCs through the c-Kit receptor. Notably, the SCF-induced increase in neovascularization activity was substantially greater in EPCs than that in human umbilical vein endothelial cells (HUVECs). SCF-induced phosphorylation of c-Kit and downstream signalling molecules was consistently found to be more potent and longer-lasting in EPCs than in HUVECs. This high responsiveness of EPCs to SCF was explained by the finding that the cell-surface expression of c-Kit is far higher in EPCs than in HUVECs. A c-Kit promoter assay revealed that the increased expression of c-Kit in EPCs could be attributed to the greater expression of stem cell leukaemia, LIM-only 2, and GATA-binding protein 2. Conclusion In addition to its documented role in the mobilization and recruitment of EPCs, our findings show that SCF directly enhances the neovascularization activity of EPCs. Furthermore, the present study provides further evidence that EPCs exhibit differentially greater responsiveness to hypoxia-inducible cytokines, including SCF, than mature endothelial cells, suggesting that EPCs in ischaemic tissues function differently from mature endothelial cells, although they exhibit very similar phenotypes.
机构:
Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Kim, Jihye
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Kim, Minhyung
Jeong, Yoonjeong
论文数: 0引用数: 0
h-index: 0
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Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Jeong, Yoonjeong
Lee, Wook-bin
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Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Lee, Wook-bin
Park, Hyojin
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Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Park, Hyojin
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Kwon, Ja-Young
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Kim, Young-Myeong
Hwang, Daehee
论文数: 0引用数: 0
h-index: 0
机构:
Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang, South Korea
Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Hwang, Daehee
Kwon, Young-Guen
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Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
机构:
INSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Razazian, Mehdi
Khosravi, Maryam
论文数: 0引用数: 0
h-index: 0
机构:
Inst Pasteur, Microenvironm & Immun Unit, F-75724 Paris, France
INSERM, Unit 1224, F-75724 Paris, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Khosravi, Maryam
Bahiraii, Sheyda
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, AustriaINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Bahiraii, Sheyda
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Uzan, Georges
Shamdani, Sara
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INSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Paris Saclay Univ, F-94800 Villejuif, France
CellMedEx, F-94100 St Maur Des Fosses, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Shamdani, Sara
Naserian, Sina
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h-index: 0
机构:
INSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Paris Saclay Univ, F-94800 Villejuif, France
CellMedEx, F-94100 St Maur Des Fosses, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Naserian, Sina
[J].
WORLD JOURNAL OF STEM CELLS,
2021,
13
(08):
: 971
-
984
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Xu, Cheng-ping
Zhang, Hua-rong
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Zhang, Hua-rong
Chen, Fei-lan
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Chen, Fei-lan
Yao, Xiao-hong
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Yao, Xiao-hong
Liang, Zi-qing
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Third Mil Med Univ, Southwest Hosp, Dept Obstet & Gynecol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Liang, Zi-qing
Zhang, Rong
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Zhang, Rong
Cui, Youhong
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Cui, Youhong
Qian, Cheng
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Qian, Cheng
Bian, Xiu-wu
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Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
机构:
Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Kim, Jihye
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Kim, Minhyung
Jeong, Yoonjeong
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h-index: 0
机构:
Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Jeong, Yoonjeong
Lee, Wook-bin
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Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Lee, Wook-bin
Park, Hyojin
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机构:
Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Park, Hyojin
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Kwon, Ja-Young
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Kim, Young-Myeong
Hwang, Daehee
论文数: 0引用数: 0
h-index: 0
机构:
Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang, South Korea
Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
Hwang, Daehee
Kwon, Young-Guen
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Yonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South KoreaYonsei Univ, Dept Biochem, Coll Life Sci & Biotechnol, Seoul 120749, South Korea
机构:
INSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Razazian, Mehdi
Khosravi, Maryam
论文数: 0引用数: 0
h-index: 0
机构:
Inst Pasteur, Microenvironm & Immun Unit, F-75724 Paris, France
INSERM, Unit 1224, F-75724 Paris, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Khosravi, Maryam
Bahiraii, Sheyda
论文数: 0引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, AustriaINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Bahiraii, Sheyda
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Uzan, Georges
Shamdani, Sara
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Paris Saclay Univ, F-94800 Villejuif, France
CellMedEx, F-94100 St Maur Des Fosses, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Shamdani, Sara
Naserian, Sina
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Paris Saclay Univ, F-94800 Villejuif, France
CellMedEx, F-94100 St Maur Des Fosses, FranceINSERM, Unite Mixte Rech, Minist Def 1197, Hop Paul Brousse, Batiment Lavoisier, F-94800 Villejuif, France
Naserian, Sina
[J].
WORLD JOURNAL OF STEM CELLS,
2021,
13
(08):
: 971
-
984
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Xu, Cheng-ping
Zhang, Hua-rong
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Zhang, Hua-rong
Chen, Fei-lan
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Chen, Fei-lan
Yao, Xiao-hong
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Yao, Xiao-hong
Liang, Zi-qing
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Dept Obstet & Gynecol, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Liang, Zi-qing
Zhang, Rong
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Zhang, Rong
Cui, Youhong
论文数: 0引用数: 0
h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Cui, Youhong
Qian, Cheng
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Qian, Cheng
Bian, Xiu-wu
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h-index: 0
机构:
Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China
Third Mil Med Univ, Southwest Hosp, SW Canc Ctr, Chongqing 400038, Peoples R ChinaThird Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China