Sero-prevalence of rubella among pregnant women in India, 2017

被引：13

作者：

Muliyil, Divya Elizabeth ^{[1
]}

Singh, Pratibha ^{[2
]}

Jois, Srinivas Krishna ^{[3
]}

Otiv, Suhas ^{[4
]}

Suri, Vanita ^{[5
]}

Varma, Vishakha ^{[6
]}

Abraham, Asha Mary ^{[1
]}

Raut, Chandrakant ^{[7
]}

Gupta, Minakshi ^{[6
]}

Singh, Mini P. ^{[5
]}

Viswanathan, Rajalakshmi ^{[8
]}

Naik, Sadanand ^{[4
]}

Nag, Vijaylakshmi ^{[2
]}

Benakappa, Asha

Bavdekar, Ashish ^{[4
,9
]}

Sapkal, Gajanan ^{[8
]}

Singh, Kuldeep ^{[2
]}

Gupta, Nivedita ^{[10
]}

Verma, Sanjay ^{[5
]}

Santhanam, Sridhar ^{[1
]}

Mishra, Sudhir ^{[6
]}

Bhatnagar, Ambar ^{[2
]}

Prasad, G. R. V. ^{[5
]}

Kolekar, Jyoti ^{[4
]}

Raj, Naga ^{[11
]}

Sabarinathan, R. ^{[11
]}

Sachdeva, Ravinder Kaur ^{[5
]}

George, Suji ^{[8
]}

Chaudhary, Shyama ^{[2
]}

Verghese, Valsan Philip ^{[1
]}

Jagtap, Vishal ^{[8
]}

Bharadwaj, Manasa ^{[9
]}

Murhekar, Manoj ^{[11
]}

机构：

[1] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India

[2] All India Inst Med Sci, Jodhpur, Rajasthan, India

[3] Vanivilas Women & Childrens Hosp, Bangalore Med Coll & Res Inst, Bengaluru, Karnataka, India

[4] KEM Hosp, Pune, Maharashtra, India

[5] Postgrad Inst Med Educ & Res, Chandigarh, India

[6] Tata Main Hosp, Jamshedpur, Jharkhand, India

[7] Natl Inst Virol, Bengaluru Unit, Bengaluru, India

[8] Natl Inst Virol, Pune, Maharashtra, India

[9] Indira Gandhi Inst Child Hlth, Bengaluru, India

[10] Indian Council Med Res, New Delhi, India

[11] Natl Inst Epidemiol, R127 Tamil Nadu Housing Board, Madras 600077, Tamil Nadu, India

来源：

VACCINE | 2018年 / 36卷 / 52期

关键词：

Rubella virus; Sero-prevalence; India;

D O I：

10.1016/j.vaccine.2018.11.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: We conducted a sero-survey among pregnant women attending antenatal clinics of six hospitals which also function as sentinel sites for CRS surveillance, to estimate the prevalence of IgG antibodies against rubella. Methods: We systematically sampled 1800 pregnant women attending antenatal clinics and tested their sera for IgG antibodies against rubella. We classified sera as seropositive (titre >= 10 IU/ml), sero-negative (titre <8 IU/ml) or indeterminate (titre 8-9.9 lU/mL) per manufacturer's instructions. In a sub-sample, we estimated the titers of IgG antibodies against rubella. IgG titer of >= 10 IU/mL was considered protective. Results: Of 1800 sera tested, 1502 (83.4%) were seropositive and 24 (1.3%) were indeterminate and 274 (15.2%) were sero-negative. Rubella sero-positivity did not differ by age group, educational status or place of residence. Three hundred and eighty three (87.8%) of the 436 sera had IgG concentrations >= 10 IU/mL. Conclusion: The results of the serosurvey indicate high levels of rubella sero-positivity in pregnant women. High sero-prevalence in the absence of routine childhood immunization indicates continued transmission of rubella virus in cities where sentinel sites are located. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：7909 / 7912

页数：4

共 11 条

[1]

[Anonymous], 2011, Wkly Epidemiol Rec, V86, P301

[2]

[Anonymous], STRAT PLAN MEASL EL

[3] Rubella [J].

Banatvala, JE ;

Brown, DWG .

LANCET, 2004, 363 (9415) :1127-1137

[4] Burden of Congenital Rubella Syndrome (CRS) in India: A Systematic Review [J].

Dewan, Pooja ;

Gupta, Piyush .

INDIAN PEDIATRICS, 2012, 49 (05) :377-399

[5] Rubella [J].

Lambert, Nathaniel ;

Strebel, Peter ;

Orenstein, Walter ;

Icenogle, Joseph ;

Poland, Gregory A. .

LANCET, 2015, 385 (9984) :2297-2307

[6]

Ministry of Health and Family Welfare, 2005, FIELD GUID MEASL SUR

[7] Sentinel Surveillance for Congenital Rubella Syndrome - India, 2016-2017 [J].

Murhekar, Manoj ;

Bavdekar, Ashish ;

Benakappa, Asha ;

Santhanam, Sridhar ;

Singh, Kuldeep ;

Verma, Sanjay ;

Sapkal, Gajanan N. ;

Gupta, Nivedita ;

Verghese, Valsan Philip ;

Viswanathan, Rajlakshmi ;

Abraham, Asha Mary ;

Choudhary, Shyama ;

Deshpande, Gururajrao N. ;

George, Suji ;

Goyal, Gatima ;

Gupta, Parul Chawla ;

Jhamb, Ishani ;

John, Deepa ;

Philip, Swetha ;

Kadam, Sandeep ;

Sachdeva, Ravinder Kaur ;

Kumar, Praveen ;

Lepcha, Anjali ;

Mahantesh, S. ;

Manasa, S. ;

Nehra, Urvashi ;

Munjal, Sanjay Kumar ;

Nag, Vijaya Lakshmi ;

Naik, Sadanand ;

Raj, Naga ;

Ram, Jagat ;

Ratho, R. K. ;

Raut, C. G. ;

Rohit, Manoj Kumar ;

Sabarinathan, R. ;

Shah, Sanjay ;

Singh, Pratibba ;

Singh, Mini P. ;

Tiwari, Ashish ;

Vaid, Neelam .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2018, 67 (36) :1012-1016

[8] Increase in congenital rubella occurrence after immunisation in Greece: retrospective survey and systematic review [J].

Panagiotopoulos, T ;

Antoniadou, I ;

Valassi-Adam, E .

BRITISH MEDICAL JOURNAL, 1999, 319 (7223) :1462-1466

[9]

Skendzel LP, 1996, AM J CLIN PATHOL, V106, P170

[10]

Thapa A, 2015, MMWR-MORBID MORTAL W, V64, P613

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