Coccidioidomycosis During Pregnancy: A Review and Recommendations for Management

被引：63

作者：

Bercovitch, Robert S. ^{[1
]}

Catanzaro, Antonino ^{[1
]}

Schwartz, Brian S. ^{[2
]}

Pappagianis, Demosthenes ^{[3
]}

Watts, D. Heather ^{[4
]}

Ampel, Neil M. ^{[5
,6
]}

机构：

[1] Univ Calif San Diego, San Diego, CA 92103 USA

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

[3] Univ Calif Davis, Davis, CA 95616 USA

[4] Eunice Kennedy Shriver Natl Inst Child Hlth & Hu, Bethesda, MD USA

[5] Univ Arizona, Valley Fever Ctr, Tucson, AZ USA

[6] So Arizona Vet Affairs Hlth Care Syst, Tucson, AZ USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 04期

关键词：

CYTOCHROME-P450; OXIDOREDUCTASE; PULMONARY COCCIDIOIDOMYCOSIS; VAGINAL CANDIDIASIS; IMMITIS INFECTION; FLUCONAZOLE; THERAPY; MALFORMATIONS; EXPOSURE; INFANT; KETOCONAZOLE;

D O I：

10.1093/cid/cir410

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The severity and risk for dissemination of coccidioidomycosis are increased when infection is acquired during pregnancy. Azole antifungals are potentially teratogenic when given in the first trimester. These issues are reviewed and guidance regarding management of coccidioidomycosis during pregnancy is provided.Pregnancy is an established risk factor for the development of severe and disseminated coccidioidomycosis, particularly when infection is acquired during the later stages of gestation. Although recent studies suggest that the incidence of symptomatic coccidioidomycosis during pregnancy is decreasing and that outcome has improved, management is complicated by the observations that azole antifungal agents can be teratogenic when given to some women, particularly at high doses, early in pregnancy. This article summarizes the data on these issues and offers guidance on the management of coccidioidomycosis during pregnancy.

引用

页码：363 / 368

页数：6

共 73 条

[1] Compound heterozygous mutations of cytochrome p450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome [J].