Therapeutic effect of rotational atherectomy with implantation of drug eluting stent in heavily coronary calcified patients

Background Rotational atherectomy (RA) could facilitate the percutaneous coronary intervention (PCI) in heavily coronary calcified patients. The effectiveness and safety of this technique needs to be further evaluated. Methods & Results Eighty patients who underwent RA in our center from September 2011 to June 2014 were enrolled. The mean age was 72.4 +/- 10.4 years. The left ventricular ejection fraction (LVEF) was average 52.3% +/- 8.48% and the estimated glomerular filtration rate was 73.2 +/- 3.20 mL/min per 1.73 m(2). The coronary lesions were complex, with Syntax score 29.5 +/- 9.86. The diameter of reference vessel was 3.4 +/- 0.45 mm and the average diameter stenosis of target vessels was 80% +/- 10%. All the patients were deployed with drug eluting stents (DES) successfully after RA. The patients were followed up for 12-18 months. Kaplan-Meier plots estimated the survival rate was 93.4% and the cumulative incidence of major adverse cardiac and cerebral events (MACCE) was 25.4%. Bleeding and procedural-related complications were quite low. COX proportional hazards model for multivariate analysis demonstrated that diabetes, LVEF and maximum pressure of postdilatation were the predictors of MACCE. Conclusions RA followed by implantation of DES was effective and safe for heavily coronary calcified patients. Diabetes, LVEF and maximum pressure of postdilatation were predictive for MACCE.