Enantio selective total synthesis of the novel antiproliferative metabolite (+)-hexacyclinol

被引：25
|
作者：
Mehta, Goverdhan [1 ]
Roy, Subhrangsu [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 09期
关键词：
D O I：
10.1016/j.tetlet.2008.01.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective total synthesis of the novel bioactive epoxyquinone natural product (+)-hexacyclinol, exhibiting promising growth inhibiting activity against cancer cell lines, has been accomplished from a readily available chiron derived from the Diels-Alder adduct of cyclopentadiene and p-benzoquinone. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1458 / 1460
页数：3
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