Rapid electrochromatographic enantiomer separations on short molecularly imprinted polymer monoliths

被引：107
作者：
Schweitz, L
Andersson, LI
Nilsson, S
机构：
[1] Lund Univ, Ctr Chem & Chem Engn, SE-22100 Lund, Sweden
[2] AstraZeneca R&D Sodertalje, SE-15185 Sodertalje, Sweden
来源：
ANALYTICA CHIMICA ACTA | 2001年 / 435卷 / 01期
关键词：
capillary electrochromatography; molecularly imprinted polymer; enantiomer;
D O I：
10.1016/S0003-2670(00)01210-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Very rapid capillary electrochromatography (CEC) mode enantiomer separations of propranolol using short super-porous monolithic molecularly imprinted polymers (MIPs) were studied. MIP stationary phases were synthesised by an in situ photo-initiated polymerisation reaction. The effect of electrolyte composition on the enantiomer separation and the stability of the MIP-column performance was investigated. The optimised MIP-CEC separation system was able to resolve the enantiomers of propranolol in less than 1 min. (C) 2001 Elsevier Science B.V. All rights reserved.
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收藏
页码：43 / 47
页数：5
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