Synthesis, Crystal Structure and Biological Evaluation of 5-Arylidine derivatives of 3-Phenyl-2-(phenylimino)thiazolidin-4-one

被引:0
作者
Haroon, Muhammad [1 ]
Akhtar, Tashfeen [1 ]
Tahir, Muhammad Nawaz [2 ]
Ali, Imran [3 ]
Hameed, Shahid [4 ]
机构
[1] MUST, Dept Chem, Mirpur Azad 10250, Jammu & Kashmir, Pakistan
[2] Univ Sargodha, Dept Phys, Punjab, Pakistan
[3] MUST, Dept Biotechnol, Mirpur Azad 10250, Jammu & Kashmir, Pakistan
[4] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
来源
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2017年 / 39卷 / 04期
关键词
Thiazolidinones; Thiourea; Arylidene; Antimicrobia; X-ray crystallography;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Arylidene derivatives of 3-phenyl-2-(phenylimino) thiazolidin-4-ones are prepared by its condensation with respective aromatic aldehydes. The structures of synthesized compounds are established using FTIR, C-13-NMR, H-1-NMR, mass spectrometry. The structure of 5-(furan-2-ylmethylene)-3-phenyl-2-(phenylimino) thiazolidin-4-one (2c) is also confirmed by X-rays crystallography. The compounds were examined for their antibacterial and enzyme inhibitory effects. Some of the compounds have shown promising activities.
引用
收藏
页码:614 / 618
页数:5
相关论文
共 50 条
  • [1] An expedient synthesis of new 2-(furoxan-3-yl)thiazolidin-4-one derivatives
    Kumar, Singam Naveen
    Kumar, Chebolu Naga Sesha Sai Pavan
    Anudeep, Sri Ranga Vanarasi
    Sharma, Kirti Kumari
    Rao, Vaidya Jayathirtha
    Babu, Nanubolu Jagadeesh
    ARKIVOC, 2016, : 32 - 49
  • [2] Synthesis of 5-benzylidene-3-(3-fluoro-4-yl-morpholin-4-yl-phenylimino)-thiazolidin-4-one derivatives catalyzed by [BmIm]OH and their anti-microbial activity
    Patil, Sudhakar G.
    Bagul, Rahul R.
    Swami, Mangesh S.
    Kotharkar, Nandini
    Darade, Kalpana
    CHINESE CHEMICAL LETTERS, 2011, 22 (08) : 883 - 886
  • [3] Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo[3,2-a][1,3,5]triazine derivatives
    Younis, Mohamed H.
    Mohammed, Eman R.
    Mohamed, Abdalla R.
    Abdel-Aziz, Marwa M.
    Georgey, Hanan H.
    Gawad, Nagwa M. Abdel
    BIOORGANIC CHEMISTRY, 2022, 124
  • [4] SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL TRISUBSTITUTED QUINAZOLINE-1,3,4 OXADIAZOLE DERIVATIVES BEARING CIS-SUBSTITUTED THIOMORPHOLINE AND THIAZOLIDIN-4-ONE MOIETIES
    Prabhakar, V.
    Babu, K. Sudhakar
    Ravindranath, L. K.
    Latha, J.
    Naik, V. Krishna Murthy
    HETEROCYCLIC LETTERS, 2015, 5 (02): : 295 - 310
  • [5] Synthesis and spectral investigation of some methyl-substituted 3-(2-pyridyl)-2-(2-thienyl)thiazolidin-4-one derivatives
    Fidan, Ismail
    Kazaz, Cavit
    Sahin, Ertan
    Kaban, Seniz
    JOURNAL OF CHEMICAL RESEARCH, 2010, (05) : 296 - 300
  • [6] Synthesis of some novel C-5 and N-3 substituted 2-(2-hydroxyphenylimino)thiazolidin-4-one derivatives with broad-spectrum antimicrobial activity
    Desai, N. C.
    Satodiya, H. M.
    Rajpara, K. M.
    Joshi, V. V.
    Vaghani, H. V.
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (12) : 6063 - 6077
  • [7] Synthesis and crystal structure of 2-morpholinylthioformyl-2-phenyl-4-morpholinyl-5-phenyl-1, 3-dithiole
    Zou, JP
    Wang, XS
    Zhang, J
    Zeng, RS
    Lu, ZE
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2000, 19 (06) : 423 - 426
  • [8] Novel DABCO based acidic ionic liquid as a green protocol for the synthesis of thiazolidin-4-one derivatives and cytotoxic activity evaluation on human breast cancer cell line
    Pinate, Priyanka
    Makone, Sangita
    JOURNAL OF SULFUR CHEMISTRY, 2023, 44 (01) : 20 - 36
  • [9] Synthesis, crystal structural determination and in silco biological studies of 3,3′-ethane-1,2-diylbis(2-benzylidene-1,3-thiazolidin-4-one
    Abdel-Rahman, Laila H.
    Mohamed, Shaaban K.
    El Bakri, Youness
    Ahmad, Sajjad
    Lai, Chin-Hung
    Amer, Amer A.
    Mague, Joel T.
    Abdalla, Ehab M.
    JOURNAL OF MOLECULAR STRUCTURE, 2021, 1245
  • [10] 3-(3-(diethylamino)propyl)-2-(4-(methylthio)phenyl)thiazolidin-4-one Attenuates Scopolamine-induced Cognitive Impairment in Rats: Insights Into Neuroprotective Effects
    de Souza, Anita Avila
    Goularte, Kelen Cristiane Machado
    Piccoli, Raphaela Cassol
    Custodio, Solange Vega
    de Mello, Julia Eisenhardt
    Victor, Melinda Gomes
    Domingues, William Borges
    de Souza, Lucas Petitemberte
    Goncalves, Lais dos Santos
    Campos, Vinicius Farias
    Cunico, Wilson
    Oses, Jean Pierre
    Stefanello, Francieli Moro
    de Aguiar, Mayara Sandrielly Soares
    Spanevello, Roselia Maria
    MOLECULAR NEUROBIOLOGY, 2025,