Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes

被引：9
|
作者：
Sasaki, Ryo [1 ]
Sato, Kohei [1 ]
Kinbara, Kazushi [1 ]
机构：
[1] Tokyo Inst Technol, Sch Life Sci, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268501, Japan
来源：
CHEMISTRYOPEN | 2020年 / 9卷 / 03期
关键词：
aromatic fluorination; lipid bilayer membranes; multiblock amphiphiles; self-assembly; supramolecular chemistry; BASIC STRUCTURE; ION; MONOLAYERS; CHANNEL;
D O I：
10.1002/open.201900374
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non-fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH.
引用
收藏
页码：301 / 303
页数：3
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