A porous polymeric-hydroxyapatite scaffold used for femur fractures treatment: fabrication, analysis, and simulation

被引:69
作者
Esmaeili, Saeid [1 ]
Aghdam, Hossein Akbari [2 ]
Motififard, Mehdi [2 ]
Saber-Samandari, Saeed [1 ]
Montazeran, Amir Hussein [1 ]
Bigonah, Mohammad [3 ]
Sheikhbahaei, Erfan [4 ]
Khandan, Amirsalar [1 ]
机构
[1] Amirkabir Univ Technol, New Technol Res Ctr, Tehran 158754413, Iran
[2] Isfahan Univ Med Sci, Sch Med, Dept Orthoped Surg, Esfahan, Iran
[3] Iran Univ Sci & Technol, Dept Mech Engn, Tehran, Iran
[4] Isfahan Univ Med Sci, Sch Med, Student Res Comm, Esfahan, Iran
关键词
Bone; Hydroxyapatite; Finite elements analysis; Static and dynamic analysis; 3D printing; Femur; Fracture; BIO-NANOCOMPOSITE SCAFFOLDS; MECHANICAL-PROPERTIES; BONE; TISSUE; COMPOSITE; NANOPARTICLES; HYPERTHERMIA; ANISOTROPY; TENSILE;
D O I
10.1007/s00590-019-02530-3
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
BackgroundOne of the most common fractures in the skeleton happens in the femur. One of the important reasons for this fracture is because it is the longest bone in the body and osteoporosis affect this part a lot. The geometric complexity and anisotropy properties of this bone have received a lot of attention in the orthopedic field.MethodsIn this research, a femur designed using 3D printing machine using the middle part of the hip made of polylactic acid-hydroxyapatite (PLA-HA) nanocomposite containing 0, 5, 10, 15, and 25 wt% of ceramic nanoparticle. Three different types of loadings, including centralized loading, full-scale, and partially loaded, were applied to the designed femur bone. The finite element analysis was used to analyze biomechanical components.ResultsThe results of the analysis showed that it is possible to use the porous scaffold model for replacement in the femur having proper strength and mechanical stability. Stress-strain analysis on femoral implant with biometric HA and PLA after modeling was performed using the finite element method under static conditions in Abaqus software.ConclusionThree scaffold structures, i.e., mono-, hybrid, and zonal structures, that can be fabricated using current bioprinting techniques are also discussed with respect to scaffold design.
引用
收藏
页码:123 / 131
页数:9
相关论文
共 46 条
[1]   Preparing diopside nanoparticle scaffolds via space holder method: Simulation of the compressive strength and porosity [J].
Abdellahi, Majid ;
Najafinezhad, Aliakbar ;
Ghayour, Hamid ;
Saber-Samandari, Saeed ;
Khandan, Amirsalar .
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2017, 72 :171-181
[2]   Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration [J].
Adachi, T ;
Osako, Y ;
Tanaka, M ;
Hojo, M ;
Hollister, SJ .
BIOMATERIALS, 2006, 27 (21) :3964-3972
[3]   Investigating the effects of CNT aspect ratio and agglomeration on elastic constants of crosslinked polymer nanocomposite using multiscale modeling [J].
Aghadavoudi, Farshid ;
Golestanian, Hossein ;
Beni, Yaghoub Tadi .
POLYMER COMPOSITES, 2018, 39 (12) :4513-4523
[4]   The impacts of internal versus external fixation for tibial fractures with simultaneous acute compartment syndrome [J].
Akbari Aghdam, Hossein ;
Sheikhbahaei, Erfan ;
Hajihashemi, Hamidreza ;
Kazemi, Davoud ;
Andalib, Ali .
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2019, 29 (01) :183-187
[5]   Effects of multi-walled carbon nanotube and nanosilica on tensile properties of woven carbon fabric-reinforced epoxy composites fabricated using VARIM [J].
Ayatollahi, M. R. ;
Isfahani, R. Barbaz ;
Monfared, R. Moghimi .
JOURNAL OF COMPOSITE MATERIALS, 2017, 51 (30) :4177-4188
[6]   Experimental investigation on tribological properties of carbon fabric composites: effects of carbon nanotubes and nano-silica [J].
Ayatollahi, Majid R. ;
Monfared, R. Moghimi ;
Isfahani, R. Barbaz .
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS, 2019, 233 (05) :874-884
[7]   Mechanical validation of whole bone composite tibia models [J].
Cristofolini, L ;
Viceconti, M .
JOURNAL OF BIOMECHANICS, 2000, 33 (03) :279-288
[8]   An artificial blood vessel fabricated by 3D printing for pharmaceutical application [J].
Esmaeili, Saeid ;
Shahali, Maryam ;
Kordjamshidi, Alireza ;
Torkpoor, Zahra ;
Namdari, Farshad ;
Saber-Samandari, Saeed ;
Nejad, Mazyar Ghadiri ;
Khandan, Amirsalar .
NANOMEDICINE JOURNAL, 2019, 6 (03) :183-194
[9]  
Farazin A., 2019, J NANOANAL, DOI [10.22034/jna.2019.584848.1134, DOI 10.22034/JNA.2019.584848.1134]
[10]   Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives [J].
Fu, Qiang ;
Saiz, Eduardo ;
Rahaman, Mohamed N. ;
Tomsia, Antoni P. .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (07) :1245-1256