A case of acute fulminant multiple sclerosis treated with alemtuzumab

被引：10

作者：

Gobbin, F. ^{[1
]}

Marangi, A. ^{[1
]}

Orlandi, R. ^{[1
]}

Richelli, S. ^{[2
]}

Turatti, M. ^{[3
]}

Calabrese, M. ^{[1
]}

Forgione, A. ^{[4
]}

Alessandrini, F. ^{[5
]}

Benedetti, M. D. ^{[3
]}

Monaco, S. ^{[1
]}

Gajofatto, A. ^{[1
]}

机构：

[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[2] Osped Sacro Cuore, Unit Intens Rehabil, Verona, Italy

[3] Azienda Osped Univ Integrata, Unit Neurol B, Verona, Italy

[4] Casa Cura Pederzoli, Unit Neurol, Verona, Italy

[5] Azienda Osped Univ Integrata, Unit Neuroradiol, Verona, Italy

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2017年 / 17卷

关键词：

Fulminant multiple sclerosis; Marburg's variant multiple; Sclerosis; Alemtuzumab;

D O I：

10.1016/j.msard.2017.06.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe the case of a woman who came to our attention for acute onset and very rapidly worsening left hemiplegia, vision loss and cognitive impairment. MRI, laboratory and clinical investigations were highly suggestive of an active inflammatory demyelinating disease. Following exclusion of other possible etiologies, a diagnosis of Marburg's variant multiple sclerosis was made. After repeated high-dose steroids and plasma-exchange, the patient was treated with a first course of alemtuzumab followed by improvement of the clinical and MRI picture. This is the first reported case of Marburg type multiple sclerosis treated with alemtuzumab.

引用

页码：9 / 11

页数：3

共 4 条

[1] Fulminant Demyelinating Diseases of the Central Nervous System
Bevan, Carolyn J.
Cree, Bruce A.
[J]. SEMINARS IN NEUROLOGY, 2015, 35 (06) : 656 - 666
[2] Treatment of Marburg variant multiple sclerosis with mitoxantrone
Jeffery, DR
Lefkowitz, DS
Crittenden, JP
[J]. JOURNAL OF NEUROIMAGING, 2004, 14 (01) : 58 - 62
[3] High dose cyclophosphamide treatment in Marburg variant multiple sclerosis A case report
Nozaki, Kenkichi
Abou-Fayssal, Nada
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2010, 296 (1-2) : 121 - 123
[4] Long survival and clinical stability in Marburg's variant multiple sclerosis
Turatti, Marco
Gajofatto, Alberto
Rossi, Francesca
Vedovello, Marcella
Benedetti, Maria Donata
[J]. NEUROLOGICAL SCIENCES, 2010, 31 (06) : 807 - 811

← 1 →