Total synthesis of the neotropical poison-frog alkaloid (-)-205B

被引：63

作者：

Smith, AB ^{[1
]}

Kim, DS

机构：

[1] Univ Penn, Dept Chem, Monell Chem Senses Ctr, Philadelphia, PA 19104 USA

[2] Univ Penn, Res Struct Matter Lab, Philadelphia, PA 19104 USA

[3] Univ Penn, Res Struct Matter Lab, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 15期

关键词：

D O I：

10.1021/ol0510264

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled total synthesis of the neotropical poison-frog alkaloid (-)-205B (1) has been achieved, employing a dithiane three-component linchpin coupling, a one-pot sequential construction of the embedded indolizidine ring, and ring-closing metathesis (RCM) to arrive at the novel 8b-azaacenaphthylene ring system comprising the alkaloid. The synthesis proceeded with a longest linear sequence of 19 steps, affording (-)-1 in 5.6% overall yield.

引用

页码：3247 / 3250

页数：4

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