Mathematical models of cell cycle regulation

被引：22
作者：
Fuss, H
Dubitzky, W
Downes, CS
Kurth, MJ
机构：
[1] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland
[2] Univ Ulster, Bioinformat Res Grp, Coleraine, Londonderry, North Ireland
[3] Univ Ulster, Ctr Mol Biosci, Coleraine, Londonderry, North Ireland
来源：
BRIEFINGS IN BIOINFORMATICS | 2005年 / 6卷 / 02期
关键词：
cell cycle; computer simulation; systems biology; protein-protein interaction; regulatory networks;
D O I：
10.1093/bib/6.2.163
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The cell division cycle is a fundamental process of cell biology and a detailed understanding of its function, regulation and other underlying mechanisms is critical to many applications in biotechnology and medicine. Since a comprehensive analysis of the molecular mechanisms involved is too complex to be performed intuitively, mathematical and computational modelling techniques are essential. This paper is a review and analysis of recent approaches attempting to model cell cycle regulation by means of protein-protein interaction networks.
引用
收藏
页码：163 / 177
页数：15
相关论文
共 45 条
  • [1] Continuous and discrete mathematical models of tumor-induced angiogenesis
    Anderson, ARA
    Chaplain, MAJ
    [J]. BULLETIN OF MATHEMATICAL BIOLOGY, 1998, 60 (05) : 857 - 899
  • [2] Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feed back systems
    Angeli, D
    Ferrell, JE
    Sontag, ED
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) : 1822 - 1827
  • [3] Simulating the impact of a molecular 'decision-process' on cellular phenotype and multicellular patterns in brain tumors
    Athale, C
    Mansury, Y
    Deisboeck, TS
    [J]. JOURNAL OF THEORETICAL BIOLOGY, 2005, 233 (04) : 469 - 481
  • [4] Emergence of scaling in random networks
    Barabási, AL
    Albert, R
    [J]. SCIENCE, 1999, 286 (5439) : 509 - 512
  • [5] Integrative analysis of cell cycle control in budding yeast
    Chen, KC
    Calzone, L
    Csikasz-Nagy, A
    Cross, FR
    Novak, B
    Tyson, JJ
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (08) : 3841 - 3862
  • [6] A kinetic model of the cyclin E/Cdk2 developmental timer in Xenopus laevis embryos
    Ciliberto, A
    Petrus, MJ
    Tyson, JJ
    Sible, JC
    [J]. BIOPHYSICAL CHEMISTRY, 2003, 104 (03) : 573 - 589
  • [7] Reappraisal of serum starvation, the restriction point, G0, and G1 phase arrest points
    Cooper, S
    [J]. FASEB JOURNAL, 2003, 17 (03) : 333 - 340
  • [8] Cooper S, 2000, Prog Cell Cycle Res, V4, P27
  • [9] Testing a mathematical model of the yeast cell cycle
    Cross, FR
    Archambault, V
    Miller, M
    Klovstad, M
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (01) : 52 - 70
  • [10] CUELLAR A, 2003, CELLML 1 1 DRAFT SPE
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