Synthesis and antileishmanial activity of 1-aminoniethyl-5-substituted-3-{4′-(3"-chlorobenzyloxy)-benzoylhydrazone}-2-indolinones

被引：0

作者：

Tiwari, R. K.

Rastogi, Nisheeth ^{[1
]}

Sethi, Rakesh

Shukla, Sarveshwar ^{[2
]}

机构：

[1] Lucknow Christian Post Grad Coll, Dept Chem, Lucknow 226018, Uttar Pradesh, India

[2] Sri Jai Narain Post Grad Coll, Dept Chem, Lucknow 226001, Uttar Pradesh, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2008年 / 85卷 / 01期

关键词：

isatins; Mannich reaction; antileishmanial activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-Substituted-3-{4'-(3 ''-chlorobenzyloxy)-benzoylhydrazono)-2-indolinones (3-6) were synthesised by the condensation of 4-(3'-chlorobenzyloxy)-benzoylhydrazine (2) and 5-substituted isatins. Mannich reaction in the presence of formaldehyde and heterocyclic secondary amines on indolinones (3-6) furnished 1-aminomethyl-5-substituted-3-{4'-(3"-chlorobenzyloxy)-benzoylhydrazono}-2-indolinones (7-22). The structures of the compounds have been established by means of correct elemental analysis and spectral data (IR, PMR and Mass). The compounds have been screened for their antileishmanial potential against Leishmania donovani.

引用

页码：85 / 88

页数：4

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