Synthesis and antileishmanial activity of 1-aminoniethyl-5-substituted-3-{4′-(3"-chlorobenzyloxy)-benzoylhydrazone}-2-indolinones

5-Substituted-3-{4'-(3 ''-chlorobenzyloxy)-benzoylhydrazono)-2-indolinones (3-6) were synthesised by the condensation of 4-(3'-chlorobenzyloxy)-benzoylhydrazine (2) and 5-substituted isatins. Mannich reaction in the presence of formaldehyde and heterocyclic secondary amines on indolinones (3-6) furnished 1-aminomethyl-5-substituted-3-{4'-(3"-chlorobenzyloxy)-benzoylhydrazono}-2-indolinones (7-22). The structures of the compounds have been established by means of correct elemental analysis and spectral data (IR, PMR and Mass). The compounds have been screened for their antileishmanial potential against Leishmania donovani.