Integrated scanning laser ophthalmoscopy and optical coherence tomography for quantitative multimodal imaging of retinal degeneration and autofluorescence

被引：1

作者：

Issaei, Ali ^{[1
]}

Szczygiel, Lukasz ^{[1
]}

Hossein-Javaheri, Nima ^{[1
]}

Young, Mei ^{[1
]}

Molday, L. L. ^{[2
]}

Molday, R. S. ^{[2
]}

Sarunic, M. V. ^{[1
]}

机构：

[1] Simon Fraser Univ, Sch Engn Sci, Burnaby, BC V5A 1S6, Canada

[2] Univ British Columbia, Ctr Macular Res, Dept Biochem & Microbiol, Vancouver, BC, Canada

来源：

MULTIMODAL BIOMEDICAL IMAGING VI | 2011年 / 7892卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

SLO; OCT; Stargardt's disease; RODENT RETINA; HIGH-SPEED;

D O I：

10.1117/12.873982

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Scanning Laser Ophthalmoscopy (SLO) and Coherence Tomography (OCT) are complimentary retinal imaging modalities. Integration of SLO and OCT allows for both fluorescent detection and depth-resolved structural imaging of the retinal cell layers to be performed in-vivo. System customization is required to image rodents used in medical research by vision scientists. We are investigating multimodal SLO/OCT imaging of a rodent model of Stargardt's Macular Dystrophy which is characterized by retinal degeneration and accumulation of toxic autofluorescent lipofuscin deposits. Our new findings demonstrate the ability to track fundus autofluorescence and retinal degeneration concurrently.

引用

页数：8

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