On-chip measurement of the Brownian relaxation frequency of magnetic beads using magnetic tunneling junctions

被引：19

作者：

Donolato, M. ^{[1
]}

Sogne, E. ^{[1
]}

Dalslet, B. T. ^{[2
]}

Cantoni, M. ^{[1
]}

Petti, D. ^{[1
]}

Cao, J. ^{[3
]}

Cardoso, F. ^{[3
]}

Cardoso, S. ^{[3
]}

Freitas, P. P. ^{[3
]}

Hansen, M. F. ^{[2
]}

Bertacco, R. ^{[1
]}

机构：

[1] Politecn Milan, L NESS, Dipartimento Fis, I-22100 Como, Italy

[2] Tech Univ Denmark, DTU Nanotech, Dept Micro & Nanotechnol, DK-2800 Lyngby, Denmark

[3] INESC Microsistemas & Nanotecnol INESC MN, P-1000029 Lisbon, Portugal

来源：

APPLIED PHYSICS LETTERS | 2011年 / 98卷 / 07期

关键词：

BIOSENSORS;

D O I：

10.1063/1.3554374

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We demonstrate the detection of the Brownian relaxation frequency of 250 nm diameter magnetic beads using a lab-on-chip platform based on current lines for exciting the beads with alternating magnetic fields and highly sensitive magnetic tunnel junction (MTJ) sensors with a superparamagnetic free layer. The first harmonic out-of-phase component of the MTJ response gives the imaginary part of the magnetic bead susceptibility, which peaks at the Brownian relaxation frequency. This work paves the way to on-chip implementation of Brownian magnetorelaxometry in innovative "lab-on-a-bead" assays for biomolecular recognition. (C) 2011 American Institute of Physics. [doi:10.1063/1.3554374]

引用

页数：3

共 22 条

[21] Comparative study of magnetic beads and microplates as supports in heterogeneous amplified assay of miRNA-141 by using mismatched catalytic hairpin assembly reaction [J].

Safenkova, Irina, V ;

Burkin, Konstantin M. ;

Bodulev, Oleg L. ;

Razo, Shyatesa C. ;

Ivanov, Aleksandr, V ;

Zherdev, Anatoly, V ;

Dzantiev, Boris B. ;

Sakharov, Ivan Yu .

TALANTA, 2022, 247

[22] Magneto-controlled flow-injection device for electrochemical immunoassay of alpha-fetoprotein on magnetic beads using redox-active ferrocene derivative polymer nanospheres [J].

Li, Bin ;

Pu, Wenyuan ;

Xu, Houxi ;

Ge, Lilin ;

Kwok, Hang Fai ;

Hu, Lihong .

ANALYST, 2019, 144 (04) :1433-1441

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