Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

被引：82
作者：
Jacques, Reece [1 ]
Pal, Ritashree [1 ]
Parker, Nicholas A. [1 ]
Sear, Claire E. [1 ]
Smith, Peter W. [1 ]
Ribaucourt, Aubert [1 ]
Hodgson, David M. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 25期
基金：
英国工程与自然科学研究理事会;
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; GLYCOSIDE CENTERED STRATEGY; OLEFINIC-ESTER; CLAISEN REARRANGEMENT; BIOLOGICAL EVALUATION; CONCISE SYNTHESIS; ANALOGS; CONSTRUCTION; COMPLEX; ACID;
D O I：
10.1039/c6ob00593d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the past two decades, alkene metathesis has risen in prominence to become a significant synthetic strategy for alkene formation. Many total syntheses of natural products have used this transformation. We review the use, from 2003 to 2015, of ring-closing alkene metathesis (RCM) for the generation of dihydrofurans or -pyrans in natural product synthesis. The strategies used to assemble the RCM precursors and the subsequent use of the newly formed unsaturation will also be highlighted and placed in context.
引用
收藏
页码：5875 / 5893
页数：19
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