Diastereoselective aldol reaction of tin enolate of cyclohexanone catalyzed by metal triflates

被引：0

作者：

Yanagisawa, A ^{[1
]}

Kimura, K ^{[1
]}

Nakatsuka, Y ^{[1
]}

Yamamoto, H ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, CREST, Japan Sci & Technol Corp, Nagoya, Aichi 4648603, Japan

来源：

SYNLETT | 1998年 / 09期

关键词：

diastereoselective aldol reaction; tin enolates; metal triflates; aldehydes; chiral bis(oxazoline);

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoselective aldol reaction of tributyltin enolate of cyclohexanone with benzaldehyde was studied in the presence of a catalytic amount of various metal triflates. The highest anti selectivity was observed with Pd(OTF)(2), while Zn(OTf)(2) in THF showed moderate syn selectivity The use of (S,S)-Pr-i-pgbox 3-Cu(OTf)(2) complex as a catalyst preferentially produced the optically active syn aldol adduct with 84% ee.

引用

页码：958 / +

页数：4

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