Cytomegalovirus infection in severe burn patients monitoring by real-time polymerase chain reaction: A prospective study

被引：31

作者：

Bordes, J. ^{[1
]}

Maslin, J. ^{[2
]}

Prunet, B. ^{[1
]}

d'Aranda, E. ^{[1
]}

Lacroix, G. ^{[1
]}

Goutorbe, P. ^{[1
]}

Dantzer, E. ^{[1
]}

Meaudre, E. ^{[1
]}

机构：

[1] St Anne Hosp, Burn Ctr, Paris, France

[2] St Anne Hosp, Virol Lab, Paris, France

来源：

BURNS | 2011年 / 37卷 / 03期

关键词：

Cytomegalovirus reactivation; Burns; Polymerase chain reaction; CRITICALLY-ILL PATIENTS; THERMALLY INJURED MICE; DIAGNOSIS;

D O I：

10.1016/j.burns.2010.11.006

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Cytomegalovirus (CMV) infection has been shown to occur not rarely in critically ill patients in the past decade. However, little data are available on CMV infection in burn patients whereas their susceptibility to CMV infection has been proved. Methods: We prospectively assessed CMV viremia by real-time polymerase chain reaction and clinical outcome in immunocompetent burn patients with total burn surface area greater than 15%. Results: Twenty-nine patients were enrolled. The rate of CMV infection was of 71% in CMV seropositive burn patients, and of 12.5% in CMV seronegative burn patients. CMV reactivation was associated with a higher IGS 2 score on admission. High grade CMV viremia was associated with longer mechanical ventilation duration, higher infection number, higher transfused red blood cell number, and longer ICU stays. There were no differences on mortality rate between patients with and without CMV reactivation. Conclusion: CMV infection rate is considerable in burn patients with TBSA greater than 15%. This infection seems to be mostly due to reactivation of latently existing virus. (c) 2010 Elsevier Ltd and ISBI. All rights reserved.

引用

页码：434 / 439

页数：6

共 18 条

[1]

BALE JF, 1990, INFECT CONT HOSP EP, V11, P17

[2] Intra-abdominal bacterial infection reactivates latent pulmonary cytomegalovirus in immunocompetent mice [J].