Efficient and Complementary Methods Offering Access to Synthetically Valuable 1,2-Dibromobenzenes

被引：31

作者：

Diemer, Vincent ^{[1
]}

Leroux, Frederic R. ^{[1
]}

Colobert, Francoise ^{[1
]}

机构：

[1] Univ Strasbourg ECPM, CNRS, UMR 7509, F-67087 Strasbourg, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 02期

关键词：

Halogens; Metalation; Magnesium; Arynes; Arenes; Cross-coupling; FUSED POLYCYCLIC AROMATICS; FACILE N-ARYLATION; FUNCTIONALIZED ARYLMAGNESIUM; SELECTIVE SYNTHESIS; EXCHANGE-REACTION; O-ARYLATION; ARYNE; BENZYNE; CYCLOADDITION; DERIVATIVES;

D O I：

10.1002/ejoc.201001217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-Dibromobenzenes are highly valuable precursors for various organic transformations, in particular, reactions based on the intermediate formation of benzynes. This report describes short sequences for the synthesis of various derivatives based on regioselective bromination, ortho-metalation, and halogen/metal permutations. 1,2-Dibromo-3-iodobenzene (2f), 1,2-dibromo-4-iodobenzene (4c), and 2,3-dibromo-1,4-diiodobenzene (5e) act as intermediates in these syntheses.

引用

页码：327 / 340

页数：14

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