What do we mean when we write "senescence," "apoptosis," "necrosis," or "clearance of dying cells"?

被引:24
作者
Mevorach, Dror
Trahtemberg, Uriel
Krispin, Alon
Attalah, Mizhir
Zazoun, Jonathan
Tabib, Adi
Grau, Amir
Verbovetski-Reiner, Inna
机构
[1] Hebrew Univ Jerusalem, Rheumatol Res Ctr, Lab Cellular & Mol Immunol, Jerusalem, Israel
[2] Hadassah Univ Med Ctr, Jerusalem, Israel
来源
CLEARANCE OF DYING CELLS IN HEALTHY AND DISEASED IMMUNE SYSTEMS | 2010年 / 1209卷
关键词
apoptosis; necrosis; senescence; clearance of apoptotic cells; PHOSPHATIDYLSERINE RECEPTOR; NECROTIC CELLS; MACROPHAGE RECOGNITION; VITRONECTIN RECEPTOR; DENDRITIC-CELL; DEATH; PHAGOCYTOSIS; ENGULFMENT; NEUTROPHILS; AUTOPHAGY;
D O I
10.1111/j.1749-6632.2010.05774.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The clearance of dying cells has become an important field of research. Apart from a significant increase in our understanding of the mechanisms for uptake, cell clearance is a basic mechanism in tissue homeostasis, cancer, resolution of inflammation, induction of tolerance, and autoimmunity. Phagocytosis of dying cells is a complex process, involving many interacting molecules on the dying cell and the phagocyte, and in the microenvironment. Although much is known on the subject, there are many questions and unknown variables that remain under investigation. Naturally, different terms were developed, among which some are misused, leading sometimes to pseudoconflicts of understanding. Several receptors were described as "phosphatidylserine receptor: are they all equal?" We will revise terms such as apoptosis, primary and secondary necrosis, lysed cells, senescent cells, clearance of apoptotic cells, efferocytosis, and more. We will try to point out misnomers, misunderstandings, and contradictions, and to define a consensual vocabulary.
引用
收藏
页码:1 / 9
页数:9
相关论文
共 67 条
[1]   Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa [J].
Bianchi, Stephen M. ;
Prince, Lynne R. ;
McPhillips, Kathleen ;
Allen, Lucy ;
Marriott, Helen M. ;
Taylor, Graham W. ;
Hellewell, Paul G. ;
Sabroe, Ian ;
Dockrell, David H. ;
Henson, Peter W. ;
Whyte, Moira K. B. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (01) :35-43
[2]   Extension of life-span by introduction of telomerase into normal human cells [J].
Bodnar, AG ;
Ouellette, M ;
Frolkis, M ;
Holt, SE ;
Chiu, CP ;
Morin, GB ;
Harley, CB ;
Shay, JW ;
Lichtsteiner, S ;
Wright, WE .
SCIENCE, 1998, 279 (5349) :349-352
[3]  
BOSE J, 2004, J BIOL LONDON, V3, pNIL5
[4]   Cellular senescence: when bad things happen to good cells [J].
Campisi, Judith ;
di Fagagna, Fabrizio d'Adda .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (09) :729-740
[5]   JMJD6 is a histone arginine demethylase [J].
Chang, Bingsheng ;
Chen, Yue ;
Zhao, Yingming ;
Bruick, Richard K. .
SCIENCE, 2007, 318 (5849) :444-447
[6]   Simple but not simpler": toward a unified picture of energy requirements in cell death [J].
Chiarugi, A .
FASEB JOURNAL, 2005, 19 (13) :1783-1788
[7]   The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity -: art. no. 26 [J].
Cikala, M ;
Alexandrova, O ;
David, CN ;
Pröschel, M ;
Stiening, B ;
Cramer, P ;
Böttger, A .
BMC CELL BIOLOGY, 2004, 5 (1)
[8]   Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals [J].
Cui, P ;
Qin, BM ;
Liu, N ;
Pan, GJ ;
Pei, DQ .
EXPERIMENTAL CELL RESEARCH, 2004, 293 (01) :154-163
[9]  
Darzynkiewicz Z, 1997, CYTOMETRY, V27, P1
[10]   Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice [J].
Devitt, A ;
Parker, KG ;
Ogden, CA ;
Oldreive, C ;
Clay, MF ;
Melville, LA ;
Bellamy, CO ;
Lacy-Hulbert, A ;
Gangloff, SC ;
Goyert, SM ;
Gregory, CD .
JOURNAL OF CELL BIOLOGY, 2004, 167 (06) :1161-1170