Studies on the drug release properties of nano-encapsulated indomethacin microparticles

被引：19
作者：
Chen, Y [1 ]
Lin, X [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
JOURNAL OF MICROENCAPSULATION | 2005年 / 22卷 / 01期
关键词：
nano-encapsulation; controlled release; indomethacin; self-assembly;
D O I：
10.1080/02652040500044972
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Indomethacin micro-crystals sized similar to 2 mu m have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on similar to 2 mu m drug micro-crystals. The release of indomethacin from coated micro-crystals was measured in aqueous solutions of pH 1.4 and 6.8. The polyelectrolyte multi-layer capsule thickness was proved to control. The results provided a method of achieving prolonged drug release through self-assembly of polymeric shells on drug microcrystals.
引用
收藏
页码：47 / 55
页数：9
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