Cobalt-catalyzed vinylation of functionalized aryl halides with vinyl acetates

被引：73

作者：

Amatore, M ^{[1
]}

Gosmini, C ^{[1
]}

Périchon, J ^{[1
]}

机构：

[1] Univ Paris 12, CNRS, UMR 7582, Lab Electrochim Catalyse & Synth Organ, F-94320 Thiais, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 06期

基金：

美国国家卫生研究院;

关键词：

catalysis; cobalt; cross-coupling; styrene; vinylation;

D O I：

10.1002/ejoc.200400897

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the preparation of styrene derivatives is described on the basis of the activation of aryl halides by low-valent cobalt species. A combination of Co-II bromide and 2,2'-bipyridine is suitable as catalyst for the cross-coupling reaction of a wide range of aromatic halides (X = Cl, Br, I), mostly bearing sensitive moieties, with vinyl acetates, These reactions proceed under mild conditions in the presence of the appropriate reducing agent to afford a-substituted styrene compounds in satisfactory to high yields. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim., Germany, 2005).

引用

页码：989 / 992

页数：4

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