Gastric H+/K+-ATPase:: targeting signals in the regulation of physiologic function

被引：11

作者：

Caplan, MJ ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(98)80060-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The H+/K+-ATPase of gastric parietal cells catalyzes acid secretion in the stomach. Regulation of this pump's function involves its targeting to an intracellular storage compartment, which fuses with the apical plasma membrane in response to secretagogue stimulation. The H+/K+-ATPase must also be returned to this intracellular storage compartment to inactivate acid secretion, Recent research suggests that a number of targeting signals and protein-protein interactions participate in governing this process.

引用

页码：468 / 473

页数：6

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