Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

被引:43
作者
Montero-Vilchez, Trinidad [1 ,2 ]
Sierra-Sanchez, Alvaro [2 ,3 ]
Sanchez-Diaz, Manuel [1 ,2 ]
Quinones-Vico, Maria Isabel [2 ,3 ,4 ]
Sanabria-de-la-Torre, Raquel [2 ,3 ,4 ]
Martinez-Lopez, Antonio [1 ,2 ]
Arias-Santiago, Salvador [1 ,2 ,3 ,4 ]
机构
[1] Virgen Nieves Univ Hosp, Dept Dermatol, Granada, Spain
[2] Biosanit Inst Granada Ibs GRANADA, Granada, Spain
[3] Andalusian Network Design & Translat Adv Therapie, Virgen Nieves Univ Hosp, Cell Prod & Tissue Engn Unit, Granada, Spain
[4] Univ Granada, Dept Dermatol, Fac Med, Granada, Spain
关键词
advanced therapy; conditioned medium; dermatology; mesenchymal stem cells; stem cells; JELLY STEM-CELLS; IN-VITRO; THERAPY; PHOTOBIOMODULATION; REJUVENATION; FIBROBLASTS; MIGRATION; EFFICACY; EXOSOMES; FIBROSIS;
D O I
10.3389/fcell.2021.654210
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
引用
收藏
页数:55
相关论文
共 119 条
[71]   Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity [J].
Montero-Vilchez, Trinidad ;
Segura-Fernandez-Nogueras, Maria-Victoria ;
Perez-Rodriguez, Isabel ;
Soler-Gongora, Miguel ;
Martinez-Lopez, Antonio ;
Fernandez-Gonzalez, Ana ;
Molina-Leyva, Alejandro ;
Arias-Santiago, Salvador .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (02) :1-12
[72]   Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium [J].
Narita, Keigo ;
Fukuoka, Hirotaro ;
Sekiyama, Takuya ;
Suga, Hirotaka ;
Harii, Kiyonori .
DERMATOLOGIC SURGERY, 2020, 46 (06) :819-825
[73]   Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth [J].
Oh, Hyun Ah ;
Kwak, Jihye ;
Kim, Beom Joon ;
Jin, Hye Jin ;
Park, Won Seok ;
Choi, Soo Jin ;
Oh, Wonil ;
Um, Soyoun .
CELLS, 2020, 9 (06)
[74]   The Potential of a Hair Follicle Mesenchymal Stem Cell-Conditioned Medium for Wound Healing and Hair Follicle Regeneration [J].
Ou, Keng-Liang ;
Kuo, Yun-Wen ;
Wu, Chia-Yu ;
Huang, Bai-Hung ;
Pai, Fang-Tzu ;
Chou, Hsin-Hua ;
Saito, Takashi ;
Ueno, Takaaki ;
Cho, Yung-Chieh ;
Huang, Mao-Suan .
APPLIED SCIENCES-BASEL, 2020, 10 (08)
[75]   Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion [J].
Park, Byung-Soon ;
Kim, Won-Serk ;
Chor, Joon-Seok ;
Kim, Hyung-Ki ;
Won, Jong-Hyun ;
Ohkubo, Fumio ;
Fukuoka, Hirotaro .
BIOMEDICAL RESEARCH-TOKYO, 2010, 31 (01) :27-34
[76]   Objective analysis of volume restoration in atrophic acne scars and skin pores: a split study using human stem cell-conditioned media [J].
Park, Chan Seong ;
Park, Ji-Hye ;
Kim, Cho Rok ;
Lee, Jong Hee .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2021, 32 (01) :73-77
[77]   Adipose-derived stem cells attenuate atopic dermatitis-like skin lesions in NC/Nga mice [J].
Park, Hyun-Sun ;
Son, Hye-Youn ;
Choi, Min-Ha ;
Son, Youngsook ;
Kim, Sundong ;
Hong, Hyun-Sook ;
Park, Ji-Ung .
EXPERIMENTAL DERMATOLOGY, 2019, 28 (03) :300-307
[78]   Overexpression of Nanog in amniotic fluid-derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration [J].
Park, Junghyun ;
Jun, Eun Kyoung ;
Son, Daryeon ;
Hong, Wonjun ;
Jang, Jihoon ;
Yun, Wonjin ;
Yoon, Byung Sun ;
Song, Gwonhwa ;
Kim, In Yong ;
You, Seungkwon .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, 51 (7) :1-15
[79]   Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells [J].
Park, Junghyun ;
Lee, Jung Han ;
Yoon, Byung Sun ;
Jun, Eun Kyoung ;
Lee, Gilju ;
Kim, In Yong ;
You, Seungkwon .
STEM CELL RESEARCH & THERAPY, 2018, 9
[80]   Prospect of Stem Cell Conditioned Medium in Regenerative Medicine [J].
Pawitan, Jeanne Adiwinata .
BIOMED RESEARCH INTERNATIONAL, 2014, 2014