Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

被引：43
作者：
Montero-Vilchez, Trinidad [1 ,2 ]
Sierra-Sanchez, Alvaro [2 ,3 ]
Sanchez-Diaz, Manuel [1 ,2 ]
Quinones-Vico, Maria Isabel [2 ,3 ,4 ]
Sanabria-de-la-Torre, Raquel [2 ,3 ,4 ]
Martinez-Lopez, Antonio [1 ,2 ]
Arias-Santiago, Salvador [1 ,2 ,3 ,4 ]
机构：
[1] Virgen Nieves Univ Hosp, Dept Dermatol, Granada, Spain
[2] Biosanit Inst Granada Ibs GRANADA, Granada, Spain
[3] Andalusian Network Design & Translat Adv Therapie, Virgen Nieves Univ Hosp, Cell Prod & Tissue Engn Unit, Granada, Spain
[4] Univ Granada, Dept Dermatol, Fac Med, Granada, Spain
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 09卷
关键词：
advanced therapy; conditioned medium; dermatology; mesenchymal stem cells; stem cells; JELLY STEM-CELLS; IN-VITRO; THERAPY; PHOTOBIOMODULATION; REJUVENATION; FIBROBLASTS; MIGRATION; EFFICACY; EXOSOMES; FIBROSIS;
D O I：
10.3389/fcell.2021.654210
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The skin is the largest organ of the human body, and its dysfunction is related to many diseases. There is a need to find new potential effective therapies for some skin conditions such as inflammatory diseases, wound healing, or hair restoration. Mesenchymal stromal cell (MSC)-conditioned medium (CM) provides a potential opportunity in the treatment of skin disease. Thus, the objective of this review is to evaluate the uses of MSC-CM for treating skin diseases in both animal and human models. A systematic review was conducted regarding the use of MSC-CM for treating skin conditions. One hundred one studies were analyzed. MSC-CM was evaluated in wound healing (55), hypertrophic scars (9), flap reperfusion (4), hair restoration (15), skin rejuvenation (15), and inflammatory skin diseases (3). MSC-CM was obtained from different MSC sources, mainly adipose tissue, bone marrow, and umbilical cord blood. MSC-CM was tested intravenously, intraperitoneally, subcutaneously, intradermally or intralesionally injected or topically applied. MSC-CM was used in both animals and humans. MSC-CM improved wound healing, hair restoration, skin rejuvenation, atopic dermatitis, and psoriasis in both animals and humans. MSC-CM also decreased hypertrophic scars and flap ischemia in animal models. In conclusion, MSC-CM is a promising therapy for skin conditions. Further studies are needed to corroborate safety and effectiveness and to standardize CM manufacturing.
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页数：55
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